|Environment & Health||ISSN: 2077-7477 eISSN: 2077-7485
No: 3 (100) - September, 2021 - Pages: 38-43
To the issue of the probable role of plant protection chemicals in the formation of population oncological incidence
Chernychenko I.O.1, Lytvychenko O.M.1, Babii V.F.1, Fedorenko Z.P.2, Tsymbaliuk S.M.3, Balenko N.V.1, Kondratenko O.Ye.1, Hlavachek D.O.1
1 State Institution "O.M. Marz³eiev Institute for Public Health of the NAMSU"
2 National Cancer Institute of MHU
3 Kyiv City Clinical Endocrinology Center of MHU
Objective: We assessed a probable role of pesticides as generalized products of plant protection means in the formation of the hormone-dependent oncological incidence in the population.
Materials and methods: In the work we analyzed the territorial features of plant protection chemicals use and the population endocrine cancer incidence data (breast and thyroid cancer in men and women, prostate cancer in men, ovarian and uterine cancer in women, calculated according to the Ukrainian standard) based on the materials from National Cancer Registry of Ukraine.
Results: Territorial dependences between gross indicators of the used chemical protection means, rates of their increase in the agriculture and indicators of the population endocrine cancer incidence were revealed. The most intensive growth was shown to be observed in the regions with a predominantly agricultural mode of production. The performed linear regression analysis confirmed a direct strong correlation between the volume of pesticide at the household use and the incidence of ovarian cancer (r = 0.89; p>0.01) and prostate cancer (r = 0.87; p>0.01).
Conclusion: Although the results of the analytical consideration of the problem and the data of linear-regression analysis indicate a possible role of pesticides in the induction of endocrine cancer, further research is needed in this field. In the future, it is important to consider the problem by classes and groups of pesticides with the possibility of the approach to the definition of the effect mechanisms.
plant protection chemicals, oncological incidence of the population, territorial features
1. Serdiuk A.M., Bazyka D.A., Tronka M.D. Natsionalnyi ohliad «Endokrynni ruinivnyky v Ukraini: stan problemy ta shliakhy yii vyrishennia» [National Review «Endocrine Disruptors in Ukraine: The State of the Problem and Ways to Solve It»]. Kyiv: Medinform; 2018: 156 p. (in Ukrainian).
3. Antomonov M.Yu. Matematicheskaya obrabotka i analiz mediko-biologicheskih dannyh. Vtoroe izdanie [ Mathematical Processing and Analysis of Biomedical Data. Second edition]. Kyiv: Medinform; 2018: 579 p. (in Russian).
4. Perelik pestytsydiv i ahrokhimikativ, dozvolenykh do vykorystannia v Ukraini: Ofitsiine vydannia [List of Pesticides and Agrochemicals Approved for Use in Ukraine: Official Publication]. Kyiv: Yunivest Media; 2016: 1023 p. (in Ukrainian).
6. Omelchuk S.T.Pestytsydy: Dovidnyk [Pesticides : Directory]. Kyiv : Interservis; 2019: 904 p. (in Ukrainian). DOI :
7. Pelo ².M. Zastosuvannia khimichnykh zasobiv u suchasnykh intehrovanykh systemakh zakhystu ovochevykh kultur yak medyko-ekolohichna problema [The Using of Chemicals in Modern Integrated Systems for the Protection of Vegetable Crops as a Medical and Environmental Problem].Ukrainian Journal of Occupational Health. 2015; 1: 67-76 (in Ukrainian). DOI : https://doi.org/10.33573/ujoh2015.01.067
9. Weichenthal S., Moase C. and Chan P. A Review of Pesticide Exposure and Cancer Incidence in the Agriculural Health Study Cohort. Environ. Health Perspect. 2010 ; 118 (8) : 1117-1125. DOI : https://doi.org/10.1289/ehp.0901731
11. Antonenko A.M., Vavrinevych O.P., Korshun M.M. and Omelchuk S.T. Hygienic Assessment of the Effects of Pesticides Application on Adult Population Morbidity with Thyroid Gland Diseases. Wiadomoœci Lekarskie. 2018 ; LXXI (2) :353–357. DOI : https://doi.org/10.36740/WLek201902123
13. Salerno C., Carcagnì A., Sacco S. et al. An Italian Population-Based Case-Control Study on the Association Between Farming and Cancer: Are Pesticides a Plausible Risk Factor?Archives of Environmental & Occupational Health. 2016 ; 71 (3) : 147-156. DOI : https://doi.org/10.1080/19338244.2015.1027808
14. Kass L., Gomez A. and Altamirano G. Relationship between Agrochemical Compounds and Mammary Gland Development and Breast Cancer. Molecular and Cellular Endocrinology. 2020 ; 508 : 10779-10783. DOI : https://doi.org/10.1016/j.mce.2020.110789
15. Lee E., Kinninger F., Giske Ursin G. et al. Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women. Int J. Environ Res Public Health. 2020 ; 17 (2) : 606-610. DOI : https://doi.org/10.3390/ijerph17020606