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1 (106), 2023


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 4 (84)   -   2017   -   Pages: 37-39
Evaluation of carcinogenic risk for the population from chlorinated drinking water consumption
Prokopov V.O.1, Lypovetska O.B.1, Kulish T.V.1, Garcavyi S.S.2
1 State Institution "O.M. Marzeiev Institute for Public Health of the NAMSU"
2 O.O. Bohomolets National Medical University, Kyiv

: 614.777:628.168: 546.13

Objective: We assessed a carcinogenic risk to the health of the population from the consumption of drinking water contaminated with volatile organochlorine compounds.

Materials and methods: The study was performed in the city of Kropyvnytskyi where tap drinking water contained volatile organochlorine compounds (OCC). Their content in water was determined by the method of gas chromatography. Determination of the exposure inhalation and dermal doses was carried out by the calculation method. To assess the hazard of the effect of the volatile OCC on the oncological morbidity of the population we applied a methodology for the evaluation of the carcinogenic risks.

Results: Drinking water monitoring showed its contamination with volatile (chloroform and bromo-dichloromethane) in the excessive amounts. The total carcinogenic risk of the effects of these substances on the population was estimated as alarming. The peroral and inhalation foreground routes of the ingress of volatile OCC of drinking water into the human organism are the foreground ones.

Conclusions: The detected level of carcinogenic risk for the population of the city of Kropyvnytskyi requires the profound epidemiological studies of oncological morbidity and the development of the preventive measures for the reduction of the OCC level in drinking water.

drinking water, volatile organochlorine compounds, carcinogenic risk
1. Prokopov V.. Pytna voda Ukrainy: medyko-ekolohichni ta sanitarno-hihienichni aspekty [Drinking Water of Ukraine: Medico-Ecological and Sanitary-and-Hygienic Aspects]. yiv : dytsyna; 2016 : 400 . (in Ukrainian).
2. U.S. EPA. Integrated Risk Information System (IRIS) on Chloroform. National Center for Environmental Assessment, Office of Research and Development. Washington, 1999. URL : https://www.epa.gov/iris/subst/0025.htm
3. Ministry of Health of Ukraine. Hazokhromatohrafichne vyznachennia tryhalohenmetaniv (khloroformu) u vodi : metodychni vkazivky 005298 [ Gas-Chromatographic Determination of Trihalohenmethane (Chloroform) in Water: Methodical Instructions 005298]. yiv; 1999 : 9 p. (in Ukrainian).
4. Rukovodstvo po otsenke riska dlia zdorovia naseleniia pri vozdeistvii khimicheskikh veshchestv, zagriazniaiushchikh okruzhaiushchuiu sredu : rukovodstvo [Manual on Risk Assessment for the Health of the Population under Effect of Chemical Substances Contaminating the Environment: Manual]. (in Russian). URL : https://ohranatruda.ru/ot_biblio/normativ/data_normativ/46/46715/index.php.
5. Toxicological Profile for Chloroform. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. 1997. URL : https://www.atsdr.cdc.gov/toxprofiles/tp6.pdf
6. Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. Washington; 2000 : 194 p.
7. WHO. Human Health Risk Assessment Toolkit: Chemical Hazards. Geneve : WHO; 2010. URL : http://apps.who.int/iris/bitstream/10665/44458/1/9789241548076_eng.pdf?ua=1
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