|Environment & Health||ISSN: 2077-7477 eISSN: 2077-7485
No: 2 (95) - June, 2020 - Pages: 70-79
Lovarian cancer incidenceand effect of environmental chemical pollution on its formation (analysis of literary data)
Chernychenko I.O.1, Balenko N.V.1, Lytvychenko O.M.1, Babii V.F.1, Hlavachek D.O.1, Kondratenko O.Ye.1
1 State Institution "O.M. Marz³eiev Institute for Public Health of the NAMSU"
Background: Currently, ovarian cancer (OC) is one of the most common malignant diseases in women with a tendency to continuing growth worldwide and a leading cause of death from gynecologic forms of cancers. Chemical contamination of the environment, including substances that have hormonal properties and injury the endocrine system, so-called endocrine disruptors (ED), is suggested to be one of the factors that increase OC incidence.
Objective: We analyzed the literary data concerning the OC incidence and the impact of the environmental chemical pollution on its formation.
Results: The analysis of the literature indicates a relatively small number of studies, especially epidemiological, concerning the connection of environmental chemicals with the incidence of OC. Epidemiological studies have shown that not only typical ED, such as polychlorinated biphenyls and pesticides (atrazine, diazinon, methoxychlor), but also other carcinogenic for human chemical factors (smoking, asbestos) have affected the increase of OC incidence.
Numerous experimental studies have shown that other pesticides and ED caused the hormonal disbalances and carcinogenesis-related effects, realized through mechanisms and signaling pathways dependent on endogenous hormones, which can lead to development and progression of OC. The ED exposures in the early period of development (in utero, neonatal) were established to cause the epigenetic effects, ovarian development disorders and proliferative-hyperplastic changes that relate to precancerous states in the animals. Epigenetic abnormalities in the animals’ ovaries are especially dangerous due to the possible formation of phenotypes sensitive to the development of cancer and their transgenerational transmission to the next generations.
Presented data suggest a significantly larger number of the ED, participating in increase of the risk of OC, which, in addition to pesticides, include a number of wide-spread ED associated with the production and use of consumer goods.
The results of the analysis confirms that OC is a topical and significant ecological, hygienic and social problem that requires the further investigations and solution of the issues related to the protection of the population from the harmful effects of the environmental chemical pollution.
ovarian cancer, incidence, chemical pollution
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