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1 (110), 2024


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 3 (108)   -   2023   -   Pages: 70-76
Supernormal concentrations of chloroform and aluminum sulfate in drinking water and their effects on metabolic processes in the organisms of laboratory animals
Tomashevska L.A.1, Prokopov V.O.1, Kravchun T.Ye.1, Lypovetska O.B.1, Didyk N.V.1, Tsytsyruk V.S.1
1 State Institution "O.M. Marzeiev Institute for Public Health of the NAMSU", Kyiv

Objective: determination of the nature and features of changes in biochemical indicators in the blood of animals under conditions of chronic exposure to different concentrations of chloroform and aluminum sulfate in drinking water in an isolated and combined state to substantiate the criteria for hygienic evaluation of their adverse effects on the body.

Materials and methods: combined effect of chloroform and aluminum sulfate on biochemical indicators.

Results: According to the results of biochemical studies, it should be noted that the most pronounced changes were observed in groups of animals that were exposed to CLF and Al in isolation at the level of 3 MPC and 5 MPC, and in groups of animals with combined exposure to the specified substances - CLF + Al at the level of 3 MPC nd 5 MPC. A decrease in the content of AsT and an increase in the level of AlT in the above experimental groups of animals may indicate functional disorders of the liver, especially its enzymatic function. The indicated changes in the content of glucose and amylase in the blood as indicators of carbohydrate volume may indicate the activation of the processes of glycogenesis and glycolysis in the animal body, which may lead to functional disorders of the pancreas.
t was established that the nature and severity of the effects depended on the nature of the influence of the studied factors (isolated or combined action), their MPC levels, and the time of exposure.

Conclusions. The nature and features of changes in biochemical indicators in the body of experimental animals during a six-month chronic sanitary-toxicological experiment with isolated and combined effects of chloroform and aluminum sulfate in drinking water may indicate metabolic disorders in organs and changes in the intensity of regenerative processes at the cellular level in response to the adverse effects of toxicants. Such a tendency to imbalance indicators can be a kind of indicator of metabolic compensatory changes in the body under the influence of a complex of factors, depending on the current level and duration of action.

drinking water, chloroform, aluminum sulfate, combined action, biochemical indicators
1. Prokopov V. Pytna voda Ukrainy: medyko-ekolohichni ta sanitarno-hihiienichni aspekty. Serdiuk A, editor. Kyiv : Medytsyna ; 2016 : 400 p. (Ukrainian).
2. Harkavyi S. [Hygienic assessment of the method of primary prevention of intestinal infections of water origin]. Suchasni infektsii. 2002 ; (2) : 64-7 (Ukrainian).
3. Hozhenko A., Petrenko N., Mokiienko A. [Biological bases of environmental safety and the use of chemical means of drinking water disinfection (literature review)]. Zhurnal AMN Ukrainy. 2008 ; 14 (1) : 134-49 (Ukrainian).
4. Prokopov V., Chychkovska H. [Hygienic evaluation of the results of monitoring of chlorinated drinking water of Ukraine regarding the content of chloroform]. In: Hihiiena naselenykh mists [Hygiene of Populated Places=Hygiene of Settlements]. Kyiv ; 2005 ; 45 : 61-6 (Ukrainian).
5. Prokopov V., Chychkovska H., Polishchuk O., Zorina O. [Chloroform in drinking water as a factor in carcinogenesis] In: Hihiiena naselenykh mists [Hygiene of Populated Places=Hygiene of Settlements]. Kyiv ; 2002 ; (3) : 131-2 (Ukrainian).
6. Yermachenko A., Kotov V., Ponomareva Y. [Halogen-containing compounds in drinking water as a risk factor for the formation of oncological morbidity in the population]. In: Hihiienichna nauka ta praktyka na rubezhi stolit: materialy XIV zizdu hihiienistiv Ukrainy [Hygienic science and practice at the turn of the century: materials of the XIV congress of hygienists of Ukraine; 2004 May 19-20; Dnipropetrovsk, Ukraine]. Dnipropetrovsk : Art-Pres ; 2004 : 204-7 (Russian).
7. Nieuwenhuijsen M.J. Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review. Occupational and Environmental Medicine. 2000 Feb 1 ; 57 (2) : 73-85. Available from: https://doi.org/10.1136/oem.57.2.73
8. Chernychenko I.O., Balenko N.V., Lytvychenko O.M. et al. [Carcinogenic Activity of Chloroform, Carbon Tetrachloride, 1,2-Dichloroethane, Trichlorethylene after Oral Combined Administration to Mice]. In: Hihiiena naselenykh mists [Hygiene of Populated Places=Hygiene of Settlements]. Kyiv ; 2002 ; (39) : 124-30 (Ukrainian).
9. Zapolskyi A. Pidhotovka vysokoiakisnoi vody v kharchovii promyslovosti [Preparation of highly acidic water in the food industry]. In: [IV International Water Forum Aqua-Ukraine-2006. International Forum Ecological Technologies 2006]. Kyiv ; 2006 : 338-9 (Ukrainian).
10. Yaroshenko K.K., Shabanov M.V. [Effectivnist of coagulative treatment of water effluents of ceramic ceramics]. In: Zbirnyk naukovykh prats Instytutu heokhimii navkolyshnoho seredovyshcha [Collection of scientific works of the Institute of Environmental Geochemistry]. Kyiv ; 2011 ; 19 : 95-101 (Ukrainian).
11. Cannata Andia J.B. Aluminium toxicity: its relationship with bone and iron metabolism. Nephrology Dialysis Transplantation. 1996 Jan 1 ; 11 (supp3) : 69-73. Available from: https://doi.org/10.1093/ndt/11.supp3.69
12. Srivastav A.L., Patel N., Chaudhary V.K. Disinfection by-products in drinking water: occurrence, toxicity and abatement. Environmental Pollution]. 2020 Dec ; 267 : 115474. Available from: https://doi.org/10.1016/j.envpol.2020.115474
13. Antomonov M.Yu. Matematicheskaia obrabotka i analiz mediko-biologicheskikh dannykh. Kiev : Medinform ; 2017 : 578. (Russian).
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