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Last issue

3 (108), 2023


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 3 (108)   -   2023   -   Pages: 70-76
Supernormal concentrations of chloroform and aluminum sulfate in drinking water and their effects on metabolic processes in the organisms of laboratory animals
Tomashevska L.A.1, Prokopov V.O.1, Kravchun T.Ye.1, Lypovetska O.B.1, Didyk N.V.1, Tsytsyruk V.S.1
1 State Institution "O.M. Marzeiev Institute for Public Health of the NAMSU", Kyiv

Objective: determination of the nature and features of changes in biochemical indicators in the blood of animals under conditions of chronic exposure to different concentrations of chloroform and aluminum sulfate in drinking water in an isolated and combined state to substantiate the criteria for hygienic evaluation of their adverse effects on the body.

Materials and methods: combined effect of chloroform and aluminum sulfate on biochemical indicators.

Results: According to the results of biochemical studies, it should be noted that the most pronounced changes were observed in groups of animals that were exposed to CLF and Al in isolation at the level of 3 MPC and 5 MPC, and in groups of animals with combined exposure to the specified substances - CLF + Al at the level of 3 MPC nd 5 MPC. A decrease in the content of AsT and an increase in the level of AlT in the above experimental groups of animals may indicate functional disorders of the liver, especially its enzymatic function. The indicated changes in the content of glucose and amylase in the blood as indicators of carbohydrate volume may indicate the activation of the processes of glycogenesis and glycolysis in the animal body, which may lead to functional disorders of the pancreas.
t was established that the nature and severity of the effects depended on the nature of the influence of the studied factors (isolated or combined action), their MPC levels, and the time of exposure.

Conclusions. The nature and features of changes in biochemical indicators in the body of experimental animals during a six-month chronic sanitary-toxicological experiment with isolated and combined effects of chloroform and aluminum sulfate in drinking water may indicate metabolic disorders in organs and changes in the intensity of regenerative processes at the cellular level in response to the adverse effects of toxicants. Such a tendency to imbalance indicators can be a kind of indicator of metabolic compensatory changes in the body under the influence of a complex of factors, depending on the current level and duration of action.

drinking water, chloroform, aluminum sulfate, combined action, biochemical indicators
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