Home Page   -   Ňditorial Board   -   Instructions to autors   -   Archive   -   Contact   -   Journal's Indexing UA   EN


Last issue

Ļ 3 (104), 2022


Support

Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 3 (104)   -   September, 2022   -   Pages: 14-22
Hyperhomocysteinemia in children is an indicator of environmental problems associated with the chÓrnobyl exclusion zone
Bandazhevskyi Yu.I.1, Dubova N.F.2
1 Ecology and Health Coordination and Analytical Centre, Ivankiv
2 Shupyk National Healthcare University of Ukraine, Kyiv

”ń : 613.22:577.112.386:577.164.1:614.876 (477.41)

ABSTRACT:
The aim of study: determination of the genetic factorís involvement (MTHFR:C677T polymorphism), which affects the activity of the main enzyme of the folate cycle, methylenetetrahydrofolate reductase, and environmental exposure, including the radiation factor, in the occurrence of hyperhomocysteinemia in children which living near the Chornobyl Exclusion Zone (ChEZ).

Research methods. Immunochemical, mathematical and statistical.

Results. Within the framework of international projects, the levels of homocysteine (Hcy) and allelic variants of the genetic polymorphism MTHFR:C677T were determined in 624 children aged 13-17 years old from Ivankivskyi and Poliskyi districts of the Kyiv region. It has been established that an increase in the level of Hcy in the blood and an increase in the number of cases of hyperhomocysteinemia in the examined groups of children are associated with forest fires in the ChEZ in 2015 and 2020. Under conditions of pronounced exposure to radioactive agents and combustion products of forest trees, the proportion of cases of hyperhomocysteinemia in groups of children with and without the T allele of the MTHFR:677 polymorphism in the genome did not have statistical differences. An indicator of ecological trouble in the ChEZ and adjacent areas is an increase, above the physiological level, in the concentration of Hcy in the blood of adolescent children with the absence of the T allele of the MTHFR:677 polymorphism in the genome.
Conclusion. In areas affected by the accident at the Chornobyl nuclear power plant, it is necessary to constantly conduct regular monitoring studies of the health of children, using tests for the content of Hcy in the blood and the state of the folate cycle genes.


KEYWORDS:
homocysteine, hyperhomocysteinemia, folate cycle genes, adolescent children, Chornobyl exclusion zone
REFERENCES:
1. Bandazhevsky Yu.I. and Dubovaya N.F. Forest Fires in the Chornobyl Exclusion Zone and Childrenís Health. PI Coordination and Analytical Center ęEcology and HealthĽ (Ivankiv, Ukraine). Kyiv : Aliant LLC; 2021: 44 p.
2. Azarov S.I., Sydorenko V.L. and Rudenko O.V. Vyvchennia protsesu nadkhodzhennia radionuklidiv u povitria pry pozhezhakh u lisakh zony vidchuzhennia ChAES [Study of the Process of Radionuclidesí Release into Atmosphere During Fires in the Forests of the ChAES]. In : Problemy pozharnoy bezopasnosti: sb. nauch. tr. [Problems of Fire Safety: Collection of scientific works]. Kyiv; 2011 ; 30 :.16-23 (in Ukrainian).
3. Bandazhevskyi Yu.I. and Dubovaya N.F. Chornobyl Catastrophe and Childrens Health. 35 Years of World Tragedy. PI Coordination and Analytical Center ęEcology and HealthĽ (Ivankiv, Ukraine). Kyiv : Aliant LLC; 2022 : 158 p.
4. Bandazhevskyi Yu.I. Chronic Cs-137 Incorporation in Children's Organs. Swiss Medical Weekly. 2003 ; 133 : 488-490.
5. Bandazhevskyi Yu.I., Dubovaya N.F., Bandazhevskaya G.S. et al. Chernobyl 25 let: inkorporirovannye radionuklidy Cs-137 i zdorove lyudei. Koordinatsionnyi analiticheskiy tsentr ęEkologiya i zdoroveĽ [Chernobyl 25 Years: Incorporated Cs-137 Radionuclides and Human Health. Coordinating Center "Ecology and Health"]. Kiev ; 2011 : 156 p. (in Russian).
6. Ganguly P. and Alam S. Role of Homocysteine in the Development of Cardiovascular Disease. Nutr J. 2015 ; 14 (6) : 2 - 10. DOI : https://doi.org/10.1186/1475-2891-14-6
7. Antoniades C., Antonopoulos A., Tousoulis D., Marinou K. and Stefanadis C. Homocysteine and Coronary Atherosclerosis: from Folate Fortification to the Recent Clinical Trials. European Heart J. 2009 ; 30 (1) : 6-15. DOI : https://doi.org/10.1093/eurheartj/ehn515
8. Varshney K.K., Gupta J.K. and Mujwar S. Homocysteine Induced Neurological Dysfunctions: A Link to Neurodegenerative Disorders. Int J Med Res Health Sci. 2019 ; 8 (4) : 135 - 146.
9. 1.Keshteli A., Baracos V. and Madsen K. Hyperhomocysteinemia as a Potential Contributor of Colorectal Cancer Development in Inflammatory Bowel Diseases : A Review. World J Gastroenterol. 2015 ; 21(4) : 1081-1090. DOI : https://doi.org/10.3748/wjg.v21.i4.1081
10. Botto L.D. and Yang Q. 5,10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: a HuGE Review. Am. J. Epidemiol. 2000 ; 151 (9) : 862-877. DOI : https://doi.org/10.1093/oxfordjournals.aje.a010290
11. Caldeira-Araķjo H., Ramos R., Florindo C., Rivera I., Castro R. and Tavares de Almeida I. Homocysteine Metabolism in Children and Adolescents: Influence of Age on Plasma Biomarkers and Correspondent Genotype Interactions. Nutrients. 2019 ; 11 : 646. DOI : https://doi.org/10.3390/nu11030646
12. Must A., Jacques P.F., Rogers G., Rosenberg I.H. and Selhub J. Serum Total Homocysteine Concentrations in Children and Adolescents: Results from the Third National Health and Nutrition Examination Survey (NHANES III), The Journal of Nutrition. 2003 ; 133 (8) : 2643-2649. DOI : https://doi.org/10.1093/jn/133.8.2643
13. äkovierovŠ H., VidomanovŠ E., Mahmood S. et al. The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. Int J Mol Sci. 2016 ; 17 (10) : 1710-1733. DOI : https://doi.org/10.3390/ijms17101733
14. Gariglio L., Riviere S., Morales A. and Rafael P. Comparison of Homocysteinemia and MTHFR677CT Polymorphism with Framingham Coronary Heart Risk Score. Archs Cardiol Mex. 2014 ; 84 (2) : 71-78. DOI : 10.1016/j.acmx.2013.12.006
15. Zahalnodozymetrychna pasportyzatsiia ta rezultaty LVLmonitorynhu v naselenykh punktakh Ukrainy, yaki zaznaly radioaktyvnoho zabrudnennia pislia Chornobylskoi katastrofy. Dani za 2011 rik. [General Dosimetric Certification and Results of WBC-Monitoring in the Settlements of Ukraine Suffered from the Radioactive Contamination after Chornobyl Catastrophe].  yiv ; 2012; Iss. 14 : 99 (in Ukrainian).
16. Bazyka D.A., Fedirko P.A., Vasylenko V.V. et al. Results of WBC Ė monitoring of firefighters participating in response to Chornobyl forest fires in April-May 2020. Problems of Radiation Medicine and Radiobiology. 2020 ; 25 : 177-187. DOI : https://doi.org/10.33145/23048336202025177187
Designed by: IPH NAMSU © Environment & Health, 2006-2022. All rights reserved.
Use of text and graphic materials of the site is allowed only upon written permission of the editoral board.