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╣ 1 (98), 2021


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 1 (98)   -   2021   -   Pages: 29-35
Breast cancer prevention in districts affected by the Chernobyl nuclear power plant accident beginning from child ages
Bandazhevskyi Yu.I.1, e-mail: Yuri.by375@gmail.com, Dubovaya N.F.2, e-mail: n_dubova@i.ua
1 Ecology and Health Coordination and Analytical Centre
2 P. L. Shupyk National Medical Academy for Post-Graduate Education, Kyiv

Ë─╩: 618.19-006.6-053.2/.9-084-02:614.876:621.039.5.004.6(477.41)

ABSTRACT:
The aim of this paper was to assess the prevalence of the T risk allele of the MTHFR:677 genetic polymorphism in a group of girls from Ivankovsky and Polessky districts located near the Chernobyl exclusion zone. In addition, we assessed variants of combined carriership of the T allele with risk alleles of other genetic polymorphisms regulating the folate cycle.

Research methods. Immunochemical, statistical.

Results. Genetic predisposition to breast cancer risk was analyzed in a group of 251 adolescent girls. Carriership of the T allele of the MTHFR:Đ677Ď polymorphism was found in 142 children (56.6%), while the homozygous T/T variant was found in 25 girls, or in 10.0% of cases. Compound heterozygosity for the 677CT/1298AC alleles of the MTHFR gene was recorded in 60 individuals, or in 23.9% of cases.

Conclusions. The revealed genetic changes in the folate cycle lead to a significant decrease in the activity of methylenetetrahydrofolate reductase, and, accordingly, to an increase in the level of homocysteine in the blood, creating conditions for the occurrence of breast cancer.
Given the high level of genetic predisposition, taking into account the constant impact on the body of radioactive elements and their decay products, the occurrence, as a consequence, of serious metabolic disorders, it is necessary to identify the breast cancer risk group of children.

KEYWORDS:
folate cycle, risk alleles, breast cancer, adolescent girls, radiation contaminated areas
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