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╣ 1 (98), 2021


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 1 (98)   -   2021   -   Pages: 29-35
Breast cancer prevention in districts affected by the Chernobyl nuclear power plant accident beginning from child ages
Bandazhevskyi Yu.I.1, e-mail: Yuri.by375@gmail.com, Dubovaya N.F.2, e-mail: n_dubova@i.ua
1 Ecology and Health Coordination and Analytical Centre
2 P. L. Shupyk National Medical Academy for Post-Graduate Education, Kyiv

Ë─╩: 618.19-006.6-053.2/.9-084-02:614.876:621.

The aim of this paper was to assess the prevalence of the T risk allele of the MTHFR:677 genetic polymorphism in a group of girls from Ivankovsky and Polessky districts located near the Chernobyl exclusion zone. In addition, we assessed variants of combined carriership of the T allele with risk alleles of other genetic polymorphisms regulating the folate cycle.

Research methods. Immunochemical, statistical.

Results. Genetic predisposition to breast cancer risk was analyzed in a group of 251 adolescent girls. Carriership of the T allele of the MTHFR:Đ677Ď polymorphism was found in 142 children (56.6%), while the homozygous T/T variant was found in 25 girls, or in 10.0% of cases. Compound heterozygosity for the 677CT/1298AC alleles of the MTHFR gene was recorded in 60 individuals, or in 23.9% of cases.

Conclusions. The revealed genetic changes in the folate cycle lead to a significant decrease in the activity of methylenetetrahydrofolate reductase, and, accordingly, to an increase in the level of homocysteine in the blood, creating conditions for the occurrence of breast cancer.
Given the high level of genetic predisposition, taking into account the constant impact on the body of radioactive elements and their decay products, the occurrence, as a consequence, of serious metabolic disorders, it is necessary to identify the breast cancer risk group of children.

folate cycle, risk alleles, breast cancer, adolescent girls, radiation contaminated areas
1. Bandazheuski Yu. and Dubovaya N. The Role of the Folate Cycle Genome in Establishing Links between Homocysteine, Hormones of the Pituitary-Thyroid Axis and Vitamins of the ź┬╗ Group in Children from the Districts, Bordering the Chernobyl Exclusion Zone. Innovative Scientific Researches: European Development Trends and Regional Aspect: Monograph. 4th ed. Riga, Latvia : Baltija Publishing; 2020 : 42-62.
2. Bandazhevsky Yu.I. and Dubovaya N.F. The State of Folate Metabolism and its Link with Thyroid System in Children after Forest Fires in the Chornobyl Exclusion Zone. Dovkillia ta zdorovia (Environment&Health). 2019 ; 2 (91) : 10-16. DOI : https://doi.org/10.32402/dovkil2019.02.010
3. ErgŘl E., Sazci A., Utkan Z. and Canturk N.Z. Polymorphisms in the MTHFR Gene are Associated with Breast Cancer. Tumor Biology. 2003 ; 24 (6) : 286-90. DOI : https://doi.org/10.1159/000076460
4. Hosseini M., Houshmand M. and Ebrahimi A. MTHFR Polymorphisms and Breast Cancer Risk. Arch Med Sci. 2011 ; 1 : 134-137. DOI : https://doi.org/10.5114/aoms.2011.20618
5. Chou Y.-C., Wu M.-H., Yu J.-C. et al. Genetic Polymorphisms of the Methylenetetrahydrofolate Reductase Gene, Plasma Folate Levels and Breast Cancer Susceptibility: A CaseľControl Study in Taiwan. Carcinogenesis. 2006; 27 (11) : 2295ľ2300. DOI : https://doi.org/10.1093/carcin/bgl108
6. Fedorenko Z., Gulak L., Ryzhov A., Gorokh Ye. et al. Osobennosti trendovykh modeley zabolevayemosti rakom grudnoy zhelezy v Ukraine posle avarii na ChAES [Characteristics of Breast Cancer Incidence Trend Models in Ukraine after the Chernobyl Accident]. Klinicheskaya onkologiya. 2012 ; 5 (1) : 11-16 (in Russian).
7. Fedorenko Z., Hulak L., Ryzhov A., Horokh Ye. et al. Risk of Breast Cancer Development in the Women of the Younger age Categories in Ukraine. Dovkillia ta zdorovia (Environment&Health). 2016 ; 1 : 36-41. DOI : https://doi.org/10.32402/dovkil2016.01.036
8. Rak v Ukraini, 2014-2015. Biuleten Natsionalnoho kantser-reiestru #17 [Cancer in Ukraine, 2014-2015. Bulletin of the National Cancer-Register #17]. Kyiv : National Cancer Institute; 2016 : 46 p. (in Ukrainian). URL : http://www.ncru.inf.ua/publications/BULL_17/index.htm
9. Rak v Ukraini, 2015-2016. Biuleten Natsionalnoho kantser-reiestru #18 [Cancer in Ukraine, 2015-2016. Bulletin of the National Cancer-Register # 18]. Kyiv : National Cancer Institute; 2017 : 46 p. (in Ukrainian). URL : http://www.ncru.inf.ua/publications/BULL_18/index.htm
10. Rak v Ukraini, 2016-2017. Biuleten Natsionalnoho kantser-reiestru #19 [Cancer in Ukraine, 2016-2017. Bulletin of the National Cancer-Register #19]. Kyiv : National Cancer Institute; 2018 : 44 p. (in Ukrainian). URL : http://www.ncru.inf.ua/publications/BULL_19/index.htm
11. Rak v Ukraini, 2017-2018. Biuleten Natsionalnoho kantser-reiestru #20 [Cancer in Ukraine, 2017-2018. Bulletin of the National Cancer-Register #20]. Kyiv : National Cancer Institute; 2019 : 46 p. URL : http://www.ncru.inf.ua/publications/BULL_20/index.htm. (in Ukrainian). http://www.ncru.inf.ua/publications/BULL_20/index.htm
12. Rak v Ukraini, 2018-2019. Biuleten Natsionalnoho kantser-reiestru #21 [Cancer in Ukraine, 2018-2019. Bulletin of the National Cancer-Register #21]. Kyiv : National Cancer Institute; 2020 : 46 p. URL : http://www.ncru.inf.ua/publications/BULL_21/index.htm. (in Ukrainian). http://www.ncru.inf.ua/publications/BULL_21/index.htm
13. Kumar P. and Rai U. Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Breast Cancer Risk: Evidence for Genetic Susceptibility. Meta Gene. 2015 ; 6 : 72-84. DOI : https://doi.org/10.1016/j.mgene.2015.08.008
14. Waseem M., Kumar S.S., Serajuddin M., Mahdi F. et al. Association of MTHFR (C677T) Gene Polymorphism with Breast Cancer in North India. Biomarkers in Cancer. 2016. Vol. 8. P. 111-117. DOI : https://doi.org/10.4137/BIC.S40446
15. Bandazhevsky Yu.I., Dubova N.F. The Role of Genome of Folate Metabolism in the Occurrence of Hyperhomocysteinemia in Children from the Areas Affected by the Chernobyl Nuclear Power Plant Accident. Scientific and Practical Collection źChernobyl: Ecology and Health╗. Ivankov: PI Coordination and Analytical Center źEcology and health╗ ; Dnipro: Serednyak Ď.╩. ; 2017 ; 6 : 27-35.
16. Zhang X., Liu T., Li Y. and Li S. Association between MTHFR 677C/T and 1298A/C Gene Polymorphisms and Breast Cancer Risk. Genet. Mol. Res. 2015 ; 14 (4) : 16425-16430. DOI : https://doi.org/10.4238/2015.December.9.12
17. Grechanina E.Ya., Malaton R., Grechanina Yu.B. et al. Nasledstvennye narusheniya obmena serosoderzhashchikh aminokislot [Hereditary Metabolic Disorders of Sulfur-Containing Amino Acids]. Rossiyskiy vestnik perinatalogii i pediatrii. 2008 ; 6 : 57-65 (in Russian).
18. Vayner A.S., Kudryavtseva E.A., Zhechev D.A. et al. Issledovaniye assotsiatsii polimorfizma genovfolatnogo obmena s riskom vrozhdennykh anomaliy razvitiya [Study of the Association of Folate Metabolism Gene Polymorphism with the Risk of Congenital Malformations]. Mat I ditya v Kuzbasse. 2011 ; 3(46) :10-16 (in Russian).
19. Bandazhevskyi Yu.I. and Dubova N.F. Pozhezhi lisu v Chornobylskii zoni vidchuzhennia ta zdorovia ditei [Forest Fires in the Chornobyl Exclusion Zone and Children's Health]. Ivankiv, Ukraine : Coordination Analytical Center "Ecology and Healthö; Dnipro, Ukraine : Serednyak Ď.╩. ; 2020 : 42 p. (in Ukrainian).
20. Bandazhevsky Yu.I., Dubova N.F. State of Folate Metabolism and Health of Children Living in Areas Contaminated with Radioactive Elements as a Result of the Chernobyl Nuclear Power Plant Accident. Scientific and practical collection źChernobyl: ecology and health╗. Ivankov: PI Coordination and Analytical Center źEcology and health╗ ; Dnipro: Serednyak Ď.╩., 2017. Issue 6. P. 16-26.
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