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№ 3 (92), 2019


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Американського національного інституту здоров'я
Міжнародного центру Фогаті
та Іллінойським університетом у Чикаго

Журнал

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

Науковий журнал з проблем медичної екології, гігієни, охорони здоров'я та екологічної безпеки

Засновник:
Державна установа "Інститут громадського здоров'я ім. О.М.Марзєєва Національної академії медичних наук України"

Періодичність виходу:
чотири рази на рік

Довкілля та здоров'яISSN: 2077-7477 eISSN: 2077-7485
Номер: 2 (91)   -   Червень, 2019   -   Сторінки: 53-59
Захворюваність на рак молочної залози і роль стійких хлорорганічних забруднювачів навколишнього середовища (аналіз даних літератури)
Черниченко І.О.1, Баленко Н.В.1, Литвиченко О.М.1, Бабій В.Ф.1, Главачек Д.О.1, Кондратенко О.Є.1
1 ДУ "Інститут громадського здоров'я ім. О.М. Марзєєва НАМНУ"

УДК: 616-006.6:616.941:314.44:547.539.2

РЕФЕРАТ:
Background: Nowadays, breast cancer is the most common hormone-dependent cancer among women worldwide. Etiology of breast cancer is multifactorial. The environmental endocrine disrupting chemicals (EDCs), including persistent organochlorine pollutants, are one of supposed factors for the increase of the incidence of breast cancer.

Objective: We analyzed the literary data concerning the role of some persistent organochlorine chemicals such as DDT, dioxins and polychlorinated biphenyls in breast cancer formation.

Results: The analysis of the epidemiological studies, despite their small number, demonstrates clearly the relationship of the exposure of studied endocrine disruptors with an increased risk of breast cancer in women. It has been established that exposure of EDCs during critical time periods (in utero, neonatal and pubertal), when hormones affect cell differentiation and tissue development, can disrupt the development of breast tissues and lead to the appearance of breast cancer in adult women. The results of the analysis confirm the relevance of the problem and the need in further research and solution of the issues of the population’s protection from the harmful effects of endocrine disruptors.

КЛЮЧОВІ СЛОВА:
breast cancer, incidence, persistent organochlorine pollutions
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