Environment & Health | ISSN: 2077-7477 eISSN: 2077-7485 |
No: 3 (83) - 2017 - Pages: 14-21
The role of carcinogenic metals in the formation of thyroid cancer morbidity in the population
Balenko N.V.1, Tsymbaliuk S.M.2, Chernychenko I.O.1, Lytvychenko O.M.1, Hulchii N.V.2, Ostash O.M.1
1 State Institution "O.M. Marz³eiev Institute for Public Health of the NAMSU" 2 Kyiv City Clinical Endocrinology Centre
ÓÄÊ: 614.71 : 616-006 : 616.441
ABSTRACT:
Objective: We determined the possible mechanisms of the effect of the foreground carcinogenic metals of the atmospheric pollutions (chrome, nickel, cadmium, lead) on the formation of thyroid cancer morbidity in the population.
Materials and methods: We used a method of theoretical analysis (generalization, synthesis, abstraction) of literary data and our investigation data concerning with the peculiarities of the bioeffects of carcinogenic metals and regularities of their manifestation.
Results: The results of the performed analysis allow us to consider that metals, under chronic combined intake into the organism, resulting in numerous effects at various levels (molecular, biochemical, organ, systemic) , can affect the formation of thyroid cancer morbidity in the population by two ways: I - by means of the induction of direct and indirect (oxidative) DNA damages and epigenetic disorders in unchanged thyrocytes with a further development of genome instability, beginning of mutations, cancer; II- by means of the induction of similar damages in the primary induced knot neoplasms (goitrogenic effect), their proliferating cells are a sensitive morphological substratum for their beginning.
Prolonged existence of the complex of these changes against a background of the disorders of the immune system functions, typical for all metals, can encourage a risk of the growth and the acceleration of the development of the malignant tumors of thyroid glands among the population.
KEYWORDS:
thyroid cancer, chromium, cadmium, nickel, lead, atmospheric air, mechanisms of influence.
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