Home Page   -   ditorial Board   -   Instructions to autors   -   Archive   -   Contact   -   Journal's Indexing UA   EN


Last issue

1 (94), 2020


Support

Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 1 (94)   -   2020   -   Pages: 64
The incidence of prostate cancer and the effect of chemical environmental pollution on its formation
Chernychenko I.O.1, Balenko N.V.1, Lytvychenko O.M.1, Babii V.F.1, Hlavachek D.O.1, Kondratenko O.Ye.1
1 State Institution "O.M. Marzeiev Institute for Public Health of the NAMSU"

: 616:006:614.7:615.277.4

ABSTRACT:
Background: Nowadays prostate cancer (PC) is the second most common malignant neoplasm in males worldwide. The etiology of prostate cancer is multifactorial. The chemical environmental pollutants, including endocrine disruptors (ED) with hormonal properties, are suggested to be one of the factors which increase the PC incidence.

Objective: We analyzed the literature data relating to the effect of the chemical environmental pollutants on the organism and their role in the formation of the PC incidence.

Results: Despite a relatively small number of epidemiological studies, their analysis indicates an association of the risk of the development of PC in males with the exposure of the number of pesticides, polychlorinated biphenyls, dioxins, bisphenol A (BPA), phthalates, nonylphenol, and also some metals (cadmium) with known estrogenic properties.
Although the mechanisms of PC induction by chemical compounds are different and not fully understandable, it is assumed that they are based on estrogenic, androgenic and anti-androgenic activity and violation of signaling ways of estrogen and androgen.
The previously known typical properties of the ED effect: the critical significance of the exposure in the early (embryonic and neonatal) period of the PG development in the increase of sensitivity to carcinogenesis and increase of PC risk at aging; non-monotonous dose-response relationship and the manifestation of harmful effects at low doses level equivalent to human exposures were confirmed experimentally as an example of BPA. The identification of stem cells and progenitor cells of differentiated epithelial cells in the gland of developing animal and PG of the adult ones is a new achievement. Epigenetic reprogramming of these cells at the exposure of ED in the early period of PG development and their key role as a direct target in the development and increase of PC risk during aging of animals was shown.
It is extremely important to obtain the similar data at the humanized PG model, created by means of xenotransplantation of normal human stem cells and PG progenitor cells to the rodents, which allows us to study the direct effect of ED on the human PG.
In general, the results of the analysis demonstrate that PC is an urgent environmental-hygienic and social problem, requiring further research and solution of the issues related to the protection of the population from the harmful effects of the environmental chemical pollutants.

KEYWORDS:
prostate cancer, incidence, environmental chemical pollutions.
REFERENCES:
1. WHO/UNEP State of the Science of Endocrine Disrupting Chemicals. 2012: An Assessment of the State of the Science of Endocrine Disruptors Prepared by a Group of Experts for the United Nations Environment Programme (UNEP) and WHO. URL : http://www.who.int/ceh/publications/endocrine/en/
2. World Cancer Report / ed. by B.W. Stewart, C.P. Wild. Lyon : JAR Press; 2014 : 630 p.
3. Rochefort H. Comptes Rendus Biologies. 2017 ; 340 (9-10) : 439-445. https://doi.org/10.1016/j.crvi.2017.07.007
4. Gore A.C., Chappell V.A., Fenton S.E. Flaws J.A., Nadal A. et al. Endocr. Rev. 2015 ; 36 (6) : 593-602. https://doi.org/10.1210/er.2015-1093
5. Rodgers K.M., Udesky J.O., Rudel R.A. and Brody J.G. Environ. Res. 2018 ; 160 : 152-182. https://doi.org/10.1016/j.envres.2017.08.0
6. Chernychenko .., Balenko N.V., Lytvychenko .., Babii V.F., Hlavachek D.. and Kondratenko .Ye. Dovkillia ta zdorovia (Environment and Health). 2019 ; 2 (91) : . 53-59 (in Ukrainian). DOI : https://doi.org/10.32402/dovkil2019.02.053
7. Chernychenko .., Balenko N.V., Lytvychenko .., Babii V.F., Hlavachek D.. and Kondratenko .Ye. Dovkillia ta zdorovia (Environment and Health). 2019 ; 3 (92) : 52-60 (in Ukrainian). DOI : https://doi.org/10.32402/dovkil2019.03.052
8. Quagliariello V., Rossetti S., Cavaliere C., Di Palo R., Lamantia E. et al. Oncotarget. 2017 ; 8 (18) : 30606-30616. DOI : https://doi.org/10.18632/oncotarget.16725
9. Reznikov A.G. Experimental Oncology. 2015 ; 37 (3) : 162-172. DOI : https://doi.org/10.31768/2312-8852.2015.37(3):162-172
10. Hu D.P., Hu W.Y., Xie L., Li Y., Birch L. and Prins G.S. The Open Biotechnology Journal. 2016 ; 10 (1) : 76-97. DOI : https://doi.org/10.2174/1874070701610010076
11. Nelles J.L., Hu W.Y. and Prins G.S. Expert Rev Endocrinol Metab. 2011 ; 6 (3) : 437-451. DOI : https://doi.org/10.1586/eem.11.20
12. Prins G.S., Ye S.-H., Birch L., Zhang X., Cheong et. al. Environ. Health Perspect. 2017 ; 125 (7) : 077007. DOI : https://doi.org/10.1289/EHP1050
13. Di Donato M., Cernera G., Giovannelli P., Galasso G., Bilancio A. et al. Mol Cell Endocrinol. 2017 ; 457 : 35-42. DOI : https://doi.org/10.1016/j.mce.2017.02.045
14. Brureau L., Emeville E., Helissey C., Thome J.P., Multigner L. and Blanchet P. Int J Cancer. 2019 ; 146(3) : 657-663. DOI : https://doi.org/10.1002/ijc.32287
15. Emeville E., Giusti A., Coumoul X., Thome J.P., Blanchet P. and Multigner L. Environ. Health Perspect. 2015 ; 123 (4) : 317- 323. DOI : https://doi.org/10.1289/ehp.1408407
16. Pi N., Chia S.E., Ong C.N. and Kelly B.C. Chemosphere. 2016 ; 144 : 1505 - 1512. DOI : https://doi.org/10.1016/j.chemosphere.2015.10.020
17. Monographs on the evaluation of carcinogenic risks to humans. Chemical agens and related occupations, 2,3,7,8-tetrachlorodibenzopara-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 3,3′,4,4′,5-pentachlorobiphenyl. Lyon : IARC ; 2012 ; 100 F : 339-378.
18. Prince M.M., Ruder A.M., Hein M.J., Waters M.A., Whelan E.A. et al. Environ Health Perspect. 2006 ; 114 (10) : 1508-1514. DOI : https://doi.org/10.1289/ehp.9175
19. Ritchie J.M., Vial S.L., Fuortes L.J., Guo H., Reedy V.E. and Smith E.M. J Occup Environ Med. 2003 ; 45 (7) : 692-702. DOI : https://doi.org/10.1097/01.jom.0000071510.96740.0b
20. Charles L.E., Loomis D., Shy C.M., Newman B., Millikan R. et al. Am J Epidemiol. 2003 ; 157 (8) : 683-691. DOI : https://doi.org/10.1093/aje/kwg044
21. Balenko N.V., Sovertkova L.S., Chernychenko .., Babii V.F., Dumanskyi Yu.D., Lytvychenko .., Serdiuk Ye.. and Kondratenko .Ye. Dovkillia ta zdorovia (Environment and Health). 2018; 1 (85) : 14-19. DOI : https://doi.org/10.32402/dovkil2018.01.014
22. Corrales J., Kristofco L.A., Steele W.B., Yates B.S., Breed C.S. et al. Dose Response. 2015 ; 13 (3). DOI : https://doi.org/10.1177/1559325815598308
23. Prins G.S., Hu W.Y., Xie L., Shi G.B., Hu D.P. et al. Environ. Health Perspect. 2018 ; 126 (11) : 117001. DOI : https://doi.org/10.1289/EHP3953
24. Calafat A.M., Ye X., Wong L.Y., Reidy J.A., Needham L.L. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 20032004. Environ Health Perspect. 2008. Vol. 116 (1): 3944. DOI : https://doi.org/10.1289/ehp.10753
25. Calafat A.M., Weuve J., Ye X., Jia L.T., Hu H. et al. Environ. Health Perspect. 2009 ; 117 (4) : 639-644. DOI : https://doi.org/10.1289/ehp.0800265
26. Braun J.M., Kalkbrenner A.E., Calafat A.M., Yolton K., Ye X. et al. Pediatrics. 2011 ; 128 (5) : 873 - 882. DOI : https://doi.org/10.1542/peds.2011-1335
27. Gao H., Yang B.J., Li N., Feng L.M., Shi X.Y. et al. Medicine (Baltimore). 2015 ; 94 (1) : 211-218. DOI : https://doi.org/10.1097/MD.0000000000000211
28. Hanaoka T., Kawamura N., Hara K., Tsugane S. et al. Occup Environ Med. 2002 ; 59 (9) : 625-628. DOI : https://doi.org/10.1136/oem.59.9.625
29. Nahar M.S., Liao C., Kannan K., Dolinoy D.C. J Biochem Mol Toxicol. 2013 ;. 27 (2) : 116-123. DOI : https://doi.org/10.1002/jbt.21459
30. Bolognesi C., Castle L., Cravedi J.P., Engel K.H., Fowler P. et al. EFSA Journal. 2015 ; 13 (1) : 3978.
31. Acconcia F., Pallottini V. and Marino M. Dose Response. 2015 ; 13 (4). URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679188/ DOI : https://doi.org/10.1177/1559325815610582
32. Huang D., Wu J., Su X., Yan H. and Sun Z. Oncol Lett. 2017 ; 14 (3) : 2635-2642. DOI : https://doi.org/10.3892/ol.2017.6469
33. Tarapore P., Ying J., Ouyang B., Burke B., Bracken B. and Ho S.M. PLoS One. 2014 ; 9 (3) : e90332. DOI : https://doi.org/10.1371/journal.pone.0090332
34. Jeng H.A. Front Public Health. 2014 ; 2 : 55. DOI : https://doi.org/10.3389/fpubh.2014.00055
35. Rehman S., Usman Z., Rehman S., AlDraihem M., Rehman N. et al. Transl Androl Urol. 2018 ; 7 (3) : 490-503. DOI : https://doi.org/10.21037/tau.2018.05.17
36. Huang D.Y., Zheng C.C., Pan Q., Wu S.S., Su X. et. al. Sci Rep. 2018 ; 8 (1) : 490. DOI : https://doi.org/10.1038/s41598-017-18869-8
37. Harris C.A., Henttu P., Parker M.G. and Sumpter J.P. Environ Health Perspect. 1997 ; 105 (8) : 802-811. DOI : https://doi.org/10.1289/ehp.97105802
38. Dodson R.E., Nishioka M., Standley L.J. Perovich L.J., Brody J.G. and Rudel R.A. Environ. Health Perspect. 2012 ; 120 (7) : 935943. DOI : https://doi.org/10.1289/ehp.1104052
39. U.S. EPA. Nonylphenol (NP) and Nonylphenol Ethoxylates (NPEs) Action Plan [RIN 2070-ZA09]. Washington, DC : US EPA; 2010. URL: https://www.epa.gov/sites/production/files/2015-09/documents/rin2070-za09_np-npes_action_plan_final_2010-08-09.pdf
40. Monographs on the Evaluation of Carcinogenic Risks to Humans. Arsenic, Metals, Fibres and Dusts. Lyon : IARC; 2012 ; 100 C : 121 145.
Designed by: IPH NAMSU Environment & Health, 2006-2020. All rights reserved.
Use of text and graphic materials of the site is allowed only upon written permission of the editoral board.