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1 (94), 2020


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 1 (94)   -   2020   -   Pages: 12
Lipidperoxid at ionunder effect of electromagnetic radiation. To the issues on the mechanisms of the effect
Tomashevska L.A.1, Kravchun T.Ye.1
1 State Institution "O.M. Marzeiev Institute for Public Health of the NAMSU"

: 613.648.2 : 577.115

ABSTRACT:
The aim of the work was to study the features of lipid peroxidation in the organism of the animals under effectof electromagnetic radiation.

Material and methods.The investigations were carried out under conditions of 4-month chronic experiment on outbred white rats which were divided into groups according to the effective intensity of 2000 V / m hv, 4000 V / m hv and 6000 V / mhv.

Results.An increase ofthe LPO processes in the blood and liver has been established.These changes were manifested depending on the level of electromagnetic radiation intensity and exposure time. Non-enzymatic stimulation of Fe2 + -dependent lipid peroxidation, increase of the enzymatic NADPH-induced accumulation of TBA-active products in rat liver homogenate, increase in the dynamics of spontaneous MDA accumulation in rat blood plasma and liver homogenate were revealed.

Conclusions.Performed investigations show that the enhancement of lipid peroxidation processes is a mechanism of the manifestation of the hazardous effect of EMR, which makes it possible to develop oxidative stress and, as an indicator of intracellular disorders, can serve as a biomarker of adverse effects. The severity of activation of lipid peroxidation system allows us to consider this as a criterion for the assessment of the hazard of the electromagnetic factor.

KEYWORDS:
lipid peroxidation, electromagnetic radiation, oxidative stress
REFERENCES:
1. Grigorev Yu.G. and Vasin A.L. (eds.). Elektromagnitnye polya i naselenie (sovremennoe sostoyanie problemy) [Electromagnetic Fields and Population (Current State of the Problem)]. Moscow : izdatelstvo Rossiyskogo universiteta druzhby narodov; 2003 : 116 p. (in Russian).
2. Serdiuk .. and Dumanskyi Yu.D. Elektromahnitna bezpeka suchasna hihiienichna problema, shliakhy yii vyrishennia [Electromagnetic Safety Is a Modern Hygienic Problem, Waysto Solve It]. In :Hihiienichna nauka i praktyka na rubezhi stolit: materialy XVI zizdu hihiienistiv Ukrainy [Hygienic Science and Practiceatthe Turn of the Century: Proceeding sof the 16th Congress of Hygienist of Ukraine]. Dnipropetrovsk ; 2004 : 251-254 (in Ukrainian)
3. DSNiP 3.3.6.096-2002. Derzhavni sanitarni normy i pravyla pry roboti z dzherelamy elektromahnitnykh poliv [SSNR 3.3.6.096-2002. State Sanitary Norms and Regulations When Working with the Sources of Electromagnetic Fields]. (in Ukrainian). URL : https://zakon.rada.gov.ua/laws/show/z0203-03/stru
4. ICNIRP. Guidelines for Limiting Exposure to Time-Varying Electric, Magnetic and Electromagnetic Fields (100 kHz to 300 GHz) : DRAFT. 2018. URL : https://www.icnirp.org/cms/upload/consultation_upload/ICNIRP_RF_Guidelines_PCD_2018_07_11.pdf
5. Directive 2013/35/EU of the European Parliament and of the Council of 26 June 2013 on the Minimum Health and Safety Requirements Regarding the Exposure of Workers to the Risks Arising from Physical Agents (Electromagnetic Fields). Official Journal of the European Union.2013. L 179/1. URL : https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2013:179:0001:0021:EN:PDF
6. Dimbylow P.J. Radiat Prot Dosimetry. 2006 ; 121(3). . 236-239. DOI : https://doi.org/10.1093/rpd/ncl032
7. Akoev I.G., Alekseev S.I., Tiazhelov V.V. etal. Pervichnye mekhanizmy deistviya radiochastotnykh izlucheniy [Primary Mechanisms of Action of Radio Frequency Radiation]. In :Biologicheskie effekty EMP. Voprosy ikh ispolzovaniya : sb. nauch. tr. [Biological EffectsofElectromagnetic Fields. Issuesof Their Use: Col. Sci.Works]. Pushchino, Russia ; 1986 : 4-14 (in Russian).
8. Erin A.N., Skrypin V.I. and Prilipko L.L. Molekulyarnye mekhanizmy deistviya v biologicheskikh membranakh [Molecular Mechanisms of Action in Biological Membranes]. In :Kislorodnye radikaly v khimii, biologii I meditsine : sb. nauch. tr. [Oxygen Radicalsin Chemistry, Biologyand Medicine: Col. Sci.Works].Riga ; 1998 : 109 129 (in Russian).
9. Gabr A.A. Biological Effects of Electromagnetic Radiation: Ph.D. Thesis.Egypt, Mansoura University.Mansoura ; 2010 : 107 p.
10. Vladimirov Yu.. Patologicheskaya fiziologiya i eksperimentalnaya terapiya.1989 ; 4 : 7-17 (in Russian).
11. Printsipy nadlezhashchey laboratornoy praktiki: HOST R 53434-2009 (Natsionalnyi standart Rossiyskoy Federatsii) [Principles of Good Laboratory Practice: GOST R 53434-2009 (National Standard of the Russian Federation)]. oscow : Standartinform; 2009 (in Russian).
12. Zahalni etychni pryntsypy eksperymentiv na tvarynakh (dokument rozroblenyi robochoiu hrupoiu Konhresu pid kerivnytstvom chl.-kor. NAN i AMN Ukrainy O.H. Reznikova) [General Ethical Principles of Animal Experiments (Document Developed by the Congress Working Group Under the Leadership of O.H. Reznikov, NAS Corresponding Member and AMS of Ukraine)]. Endokrynolohiia. 2003. .8, 1. . 142-145(inUkrainian).
13. Danilova L.. Spravochnyk po laboratornym metodam issledovaniya [Handbook of Laboratory Research Methods]. Sankt-Peterburg :Piter ; 2003 : 736 p. (in Russian).
14. KamyshnikovV.S. Spravochnikpokliniko-biokhimicheskimissledovaniyam I laboratornoydiagnostike[HandbookofClinicalandBiochemicalStudiesandLaboratoryDiagnostics].3-rd ed. Moscow :MEDpressinform; 2009 : 896 p. (in Russian).
15. Kazimirko V.K., Ivanitskaya L.M., Kutovoy V.V., Dubkova A.G. and Silanteva T.S. Ukrainskyi revmatolohichnyi zhurnal. 2014 ; 57 (3) : 13-17 (in Russian).
16. Tomashevska L.. and Kravchun .Ye. Dovkillia ta zdorovia (Environment and Health). 2018 ; 4 (89) : 4-10 (in Ukrainian). DOI : https://doi.org/10.32402/dovkil2018.04.004
17. Tiazhka .V. and Zahorodnia Ya.. Perinatologiya I pediatriya. 2016 ; 2 (66) : 101-105 (in Ukrainian). DOI : https://doi.org/10.15574/PP.2016.66.101
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