|Environment & Health||ISSN: 2077-7477 eISSN: 2077-7485
No: 2 (103) - June, 2022 - Pages: 10-15
Genetic control of homocysteine metabolism in children living near the chîrnobyl exclusion zone
Bandazhevskyi Yu.I.1, Dubova N.F.2
1 Ecology and Health Coordination and Analytical Centre, Ivankiv
2 Shupyk National Healthcare University of Ukraine, Kyiv
The aim of study: to determine the involvement of folate cycle genes in the occurrence of hyperhomocysteinemia in children from Ivankivskyi district of Kyiv region of Ukraine 35 years after the accident at the Chornobyl nuclear power plant.
Research methods. Immunochemical, mathematical and statistical.
Results. Homocysteine levels were determined in 217 children aged 12-17 from Ivankivskyi district of Kyiv region, as well as genetic polymorphisms of the folate cycle. An excess of homocysteine in the blood over 10 µmol/l (a state of hyperhomocysteinemia) was detected in 65.44 % (142 out of 217) of those examined, among boys – 69.79 % (67 out of 96), among girls – 61.98 % (75 out of 121). The largest proportion of hyperhomocysteinemia cases was registered in the subgroup of children with the basic polymorphism MTHFR: 677TT – 94.44 % of cases. In most cases, hyperhomocysteinemia in children was associated with an environmental factor, including radioactive elements and their decay products. The system for the prevention of hyperhomocysteinemia and its consequences in children living in areas affected by the accident at the Chornobyl nuclear power plant should include regular monitoring of the content of radionuclides in the body of children and locally produced food, the content of homocysteine in the blood, and assessment of the state of folate cycle genes.
homocysteine, adolescent children, radionuclides, Chornobyl åxclusion zone
1. Bandazhevsky Yu.I. and Dubovaya N.F. Gipergomotsisteinemiya i B12-folievyi defitsit u detey, prozhivayushchikh na territorii, zagryaznennoy v rezultate avarii na Chernobylskoy atomnoy elektrostantsii [Hyperhomocysteinemia and B12-Folic Deficiency Among Children Who Live on the Territory Contaminated with Radionuclides as a Result of the Accident at the Chernobyl Nuclear Power Plant]. Pediatria. Vostochnaya Evropa. 2017 ; 5 (1) : 25-32 (in Russian).
3. Polushin A.Yu., Odinak M.M., Yanishevskiy S.N. et al. Gipergomotsisteinemiya – predictor tyazhesti insulta na fone obshirnosti povrezhdeniya mozgovogo veshchestva [Hyperhomocysteinemia is a Predictor of Stroke Severity Against the Background of Extensive Brain Damage]. Vestnik Rossiyskoy voenno-meditsinskoy akademii. 2013 ; 4: 89 – 94 (in Russian).
4. Keshteli A., Baracos V. and Madsen K. Hyperhomocysteinemia as a Potential Contributor of Colorectal Cancer Development in Inflammatory Bowel Diseases : A Review. World J Gastroenterol. 2015 ; 21(4) : 1081 -1090. DOI : https://doi.org/10.3748/wjg.v21.i4.1081
5. Tronko M., Bogdanova T., Saenko V. et al. Thyroid Cancer in Ukraine after Chernobyl. Dosimetry, Epidemiology, Pathology, Molecular Biology. Nagasaki : Nagasaki Association for Hibakushas ´Medical Care (NASHIM); 2014 : 175 p.
6. Bandazhevsky Yu.I. Improvement of Quality of Life in the Population of Ivankov and Polesie Districts by Preventing Conditions Associated with the Impact of Environmental Factors. Chernobyl: Ecology and Health : Scientific and Practical Collection. Ivankiv PI Coordination and Analytical Center «Ecology and Health». Dnipro : Seredniak Ò.Ê. ; 2017 ; 6 :12-15.
7. Bandazhevsky Yu.I. and Dubovaya N.F. Forest Fires in the Chernobyl Exclusion Zone and Children’s Health. Ivankiv PI Coordination and Analytical Center «Ecology and Health». Kyiv : Aliant LLC; 2021 : 44 p.
8. Bandazhevsky Yu.I. and Dubovaya N.F. Chernobyl Catastrophe and Childrens Health. 35 Years of World Tragedy. Ivankiv PI Coordination and Analytical Center «Ecology and Health». Kyiv : Aliant LLC ; 2022 : 158 p.
9. Bandazhevsky Yu.I., Dubovaya N.F., Bandazhevskaya G.S. et al. Chernobyl 25 let: inkorporirovannye radionuklidy Cs-137 I zdorovie lyudey [Chernobyl 25 Years: Incorporated Cs-137 Radionuclides and Human Health]. Kiev ; 2011 : 156 p. (in Russian).