|Environment & Health||ISSN: 2077-7477 eISSN: 2077-7485
No: 1 (85) - March, 2018 - Pages: 14-19
Investigations of genotoxicity of extremely low frequency electromagnetic field.
current state (the first report)
Balenko N.V.1, Sovertkova L.S.1, Chernychenko I.O.1, Babii V.F.1, Dumanskii Yu.D.1, Litvichenko O.M.1, Serdiuk Ye.A.1, Kondratenko O.Ye.1
1 State Institution "O.M. Marz³eiev Institute for Public Health of the NAMSU"
Objective: We analyzed the state of the issue on the experimental study of genotoxicity of extremely low frequency electromagnetic fields (ELF EMF).
Materials and methods: We performed the analysis of literary data on the experimental investigations of ELF EMF genotoxicity.
Results: The genotoxic effects of ELF EMF in the experiment were studied by many authors. Genotoxicity was assessed by means of the detection of the frequency of chromosomal aberration, sister chromatid exchange, DNA damage (Comet test), formation of micronuclei, and presence of 8-hydroxy-2-deoxyguanosine (biomarker of DNA oxidative damage). Investigations were conducted both in vivo and in vitro. Obtained results were dissimilar and contradictory. However, a number of the works, confirming the genotoxicity of ELF EMF in the range from 35 μT to 5 mT in vitro and from 100 μT to 5 mT in vivo and proving the oxidative mechanisms of DNA damage, increased last years. A role of the alterations of DNA repair processes and epigenetic changes, caused by ELF EMF, is suggested.
Conclusion: Owing to data limitation, there is a need of further biophysical and molecule-biological studies for the defection of the basic mechanisms in ELF EMF genotoxic effects realization and a study of dose-time regularities of their manifestations at the effect of ELF EMF levels affecting a human under environmental and occupational conditions, taking into account the effect of the accompanying chemical and physical factors as well. The solution of these problems is necessary for the development of the effective measures for the protection of the population from ELF EMF harmful impact.
extremely low frequency electromagnetic fields (ELF EMF), genotoxicity in vivo, in vitro.
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