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3 (92), 2019


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 2 (78)   -   2016   -   Pages: 9-13
On possible mechanisms of atmospheric formaldehyde effect on the formation of the population thyroid cancer morbidity
CHERNICHENKO I.O.1, BALENKO N.V.1, TSYMBALIUK S.N.2, OSTASH O.M.1
1 STATE INSTITUTION O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH NAMSU
2 Kyiv City Clinical Endocrinology Centre

: 614.71 : 547.281.1 : 612.44 : 616-006

SUMMRY:
Objective. We clarified possible mechanisms of the formaldehyde effect on the formation of the population thyroid cancer morbidity.
Materials and methods. We analyzed our own data and literary ones with the help of the method of theoretical analysis (generalization, synthesis and abstraction) of the scientific and methodological literature on the biological effects of this compound and the regularities of their manifestation.
Results. Formaldehyde inhalation can induce genotoxic and toxic damages in the tissues distant from the primary contact in humans and laboratory animals (circulating blood cells, bone marrow respectively). Furthermore, formaldehyde promotes a carcinogenesis and enhances an immunosupression at the joint administration with other carcinogens. According to these data an induction of genotoxic and toxic changes in thyroid gland and their accumulation at the chronic exposure of formaldehyde with other atmospheric carcinogens may be observed and in conjunction with the immunosupression it may lead to the strengthening of the combined effect and will increase the risk of thyroid cancer among population.
Under conditions of the occupational exposure formaldehyde can become a dominant factor in the formation of the professional thyroid cancer morbidity.

KEYWORDS:
thyroid gland, tumors, formaldehyde, mechanisms of the effect.
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