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1 (110), 2024


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 2 (99)   -   June, 2021   -   Pages: 44-55
Impact of some environmental chemical carcinogens on the incidence of hormone-dependent tumors and possible mechanisms of its realization (literary review)
Chernychenko I.O.,1, Balenko N.V.,1, Lytvychenko O.M.1, Babii V.F.1, Hlavachek D.O.1, Kondratenko O.Ye.1
1 SI O.M. Marzieiev Institute for Public Health, National Academy of Medical Sciences of Ukraine

: 616-006.88:614.718

Objective: We determined the possible effects of priority chemical environmental carcinogens on the incidence of hormone-dependent tumors and the mechanisms of their effect on the basis of the analysis of literature data and our own research.
Results: The performed analysis demonstrates the scanity of the research devoted to the study of chemical carcinogens which are concerned only with the class of polycyclic aromatic hydrocarbons (PAH), benzo(a)pyrene (BP), atmospheric pollution, emissions from vehicles, the cadmium heavy metal and products of smoking containing these substances. The connection with PAH (BP) and the development of breast, ovarian cancer, cadmium with the development of breast, endometrial, ovarian cancer in women and prostate cancer in men was established. Epidemiological data, combined with experimental ones, suggest a possible contribution of carcinogens into the increase of the incidence of hormone-dependent tumors. At the same time, mechanisms of action of PAH and cadmium on the development of hormone-dependent tumors are unclear. The accumulated experimental and epidemiological data allow us to conclude that the oncological danger of these carcinogens lies in the combination of genotoxic and hormone-mimetic properties; the main mechanisms, involved in the realization of the effect of BP and cadmium, are associated with changes and disorders at different levels of the structural and functional organization of the organism, including the endocrine system, which can lead to the development of tumors. The urgency of the problem of the incidence of hormone-dependent tumors and the potential role of the studied chemical carcinogens as pollutants of the environment of human functions indicate the need to take these circumstances into account when developing and implementing preventive measures.

hormone-dependent tumors, morbidity, polycyclic aromatic hydrocarbons, benz(a)pyrene, cadmium, mechanisms of effect
1. Madia F., Worth A., Whelan M. and Corvi R. Carcinogenicity Assessment: Addressing the Challenges of Cancer and Chemicals in the Environment. Environ Int. 2019 ; 128 : 417-429. DOI : https://doi.org/10.1016/j.envint.2019.04.067
2. WHO/UNEP State of the Science of Endocrine Disrupting Chemicals. 2012: An Assessment of the State of the Science of Endocrine Disruptors Prepared by a Group of Experts for the United Nations Environment Programme (UNEP) and WHO. URL: http://www.who.int/ceh/publications/endocrine/en/
3. World Cancer Report. Ed. by B.W. Stewart, C.P. Wild. Lyon: JAR Press; 2014 : 630 p.
4. Gore A.C., Chappell V.A., Fenton S.E. Flaws J.A., Nadal A. et al. Executive Summary to EDC-2: the Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr. Rev. 2015 ; 36 (6) : 593-602. DOI : https://doi.org/10.1210/er.2015-1093
5. Rodgers K.M., Udesky J.O., Rudel R.A. and Brody J.G. Environmental Chemicals and Breast Cancer: an Updated Review of Epidemiological Literature Informed by Biological Mechanisms. Environ. Res. 2018 ; 160 : 152-182. DOI : https://doi.org/10.1016/j.envres.2017.08.045
6. Mallozzi M., Leone C., Manurita F. et al. Endocrine disrupting chemicals and Endometrial Cancer: an Overview of Recent Laboratory Evidence and Epidemiological Studies. Int. J. Environ. Res. Public Health. 2017 ; 14 (3) : 334-356. DOI : https://doi.org/10.3390/ijerph14030334
7. Samtani R., Sharma N. and Garg D. Effects of Endocrine Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review. Reprod. Sci. 2017 ; 25 (1) : 7-18. DOI : https://doi.org/10.1177/1933719117711261
8. Hu D.P., Hu W.Y., Xie L., Li Y., Birch L. and Prins G.S. Actions of Estrogenic Endocrine Disrupting Chemicals on Human Prostate Stem/Progenitor Cells and Prostate Carcinogenesis. The Open Biotechnology Journal. 2016 ; 10 (1) : 76-97. DOI : https://doi.org/10.2174/1874070701610010076
9. Di Donato M., Cernera G., Giovannelli P., Galasso G., Bilancio A. et al. Recent Advances on Bisphenol-A and Endocrine Disruptor Effects on Human Prostate Cancer. Mol Cell Endocrinol. 2017 ; 457 : 35-42. DOI : https://doi.org/10.1016/j.mce.2017.02.045
10. Chernychenko I.O., Balenko N.V., Lytvychenko O.M., Babii V.F., Hlavachek D.O. and Kondratenko O.Ye. Zakhvoriuvanist na rak molochnoi zalozy i rol khimichnykh zabrudniuvachiv dovkillia (analiz danykh literatury) [Incidence of Breast Cancer and the Role of Chemical Pollutants of the Environment (Analysis of Literary Data]. Dovkillia ta zdorovia (Environment & Health). 2019 ; 3 : 52-60 (in Ukrainian).
11. Chernychenko I.O., Balenko N.V., Lytvychenko O.M., Babii V.F., Hlavachek D.O. and Kondratenko O.Ye. Zakhvoriuvanist na rak peredmikhurovoi zalozy i vplyv khimichnoho zabrudnennia navkolyshnoho seredovyshcha na yii formuvannia [The Incidence of Prostate Cancer and the Impact of Chemical Pollution on its Formation]. Dovkillia ta zdorovia (Environment & Health). 2020 ; 1 : 64-75 (in Ukrainian).
12. Chernychenko I.O., Balenko N.V., Lytvychenko O.M., Babii V.F., Hlavachek D.O. and Kondratenko O.Ye. Zakhvoriuvanist na rak yaiechnykiv i vplyv na yii formuvannia khimichnoho zabrudnennia navkolyshnoho seredovyshcha (analiz danykh literatury) [The Incidence of Ovarian Cancer and the Impact of Chemical Pollution of the Environment on its Formation (Analysis of Literary Data)]. Dovkillia ta zdorovia (Environment & Health). 2020 ; 2 : 70-79 (in Ukrainian).
13. Hiatt R.A. and Brody J.G. Environmental Determinants of Breast Cancer. Annual Review of Public Health. 2018 ; 39 : 113-133. DOI : https://doi.org/10.1146/annurev-publhealth-040617-014101
14. IARC. Monographs on the Evaluation of Carcinogenic Risks to Humans : Outdoor Air Pollution. Lyon, France: International Agency for Research on Cancer. 2016 ; 109. URL : http://monographs.iarc.fr/ENG/Monographs/vol109/mono109. pdf
15. NTP. Report on Carcinogens, 14th Edition. United States National Toxicology Program. Research Triangle Park, NC : 2016. URL: http://ntp.niehs.nih.gov/go/roc14
16. IARC. Agents Classified by the IARC Monographs, Volumes 1-109. Lyon, France: International Agency for Research on Cancer, 2013. URL : http://monographs.iarc.fr/ENG/Classification/ClassificationsAlphaOrder.pdf
17. Rudel R.A., Ackerman J.M., Attfield K.R. and Brody J.G. New Exposure Biomarkers as Tools for Breast Cancer Epidemiology, Biomonitoring and Prevention: a Systematic Approach Based on Animal Evidence. Environ. Health Perspect. 2014 ; 122 (9) : 881-895. DOI : https://doi.org/10.1289/ehp.1307455
18. Serdyuk A.M., Beletskaya E.N., Paranko N.M. and Shmatkov G.G. Tyazhelyye metally vneshney sredy i ikh vliyaniye na reproduktivnuyu funktsiyu zhenshchin [Heavy Metals of the Environment and their Impact on the Reproductive WomenFunction]. Dnepropetrovsk : Art-Press; 2004 : 148 p. (in Russian).
19. Chernychenko I.O., Lytvychenko O.M., Balenko N.V. and Sovertkova L.S. Kantserohenni spoluky povitrianoho seredovyshcha ta rak shchytopodibnoi zalozy [Carcinogenic Compounds of Air Environment and Thyroid Cancer]. Chernychenko I.O. (Ed.). Kyiv : Derkul; 2018: 224 p. (in Ukrainian).
20. White A.J., Chen J., McCullough L.E. et al. Polycyclic Aromatic Hydrocarbon (PAH)-DNA Adducts and Breast Cancer: Modification by Gene Promoter Methylation in a Population-Based Study. Cancer Causes Control. 2015; 26 (12) : 1791-802.
21. Nie J., Beyea J., Bonner M.R. et al. Exposure to Traffic Emissions throughout Life and Risk of Breast Cancer: the Western New York Exposures and Breast Cancer (WEB) Study. Cancer Causes Control. 2007 ; 18 (9) : 947-955. DOI : https://doi.org/10.1007/s10552-007-9036-2
22. Pan S.Y., Morrison H., Gibbons L. et al. Breast Cancer Risk Associated with Residential Proximity to Industrial Plants in Canada. J. Occup. Environ. Med. 2011 ; 53 (5) : 522-529. DOI : https://doi.org/10.1097/JOM.0b013e318216d0b3
23. Mordukhovich I., Beyea J., Herring A.H. et al. Polymorphisms in DNA Repair Genes, Traffic-Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence. Int. J. Cancer. 2016 ; 139 (2) : 310-321. DOI : https://doi.org/10.1002/ijc.30079
24. Liu R., Nelson D.O., Hurley S. et al. Residential Exposure to Estrogen Disrupting Hazardous Air Pollutants and Breast Cancer Risk: the California Teachers Study. Epidemiology. 2015 ; 26 (3) : 365-373. DOI : https://doi.org/10.1097/EDE.0000000000000277
25. Cogliano V.J., Baan R., Straif K. et al. Preventable Exposures Associated with Human Cancers. J Natl Cancer Inst. 2011 ; 103 (24) : 1827-1839. DOI : https://doi.org/10.1093/jnci/djr483
26. Mun S.A., Larin S.A., Brailovskiy V.V. et al. Benz(a)piren v atmosfernom vozdukhe i onkologicheskaya zabolevayemost v Kemerovo [Benz(a)pyrene in Ambient Air and Oncological Morbidity in Kemerovo]. Gigiena i sanitariia. 2006 ; 4 : 28-29 (in Russian).
27. IARC. Monographs on the Evaluation of Carcinogenic Ricks to Humans, Volume 100E: Personal Habits and Indoos Combustions. Lyon, France : IARC; 2012 ; 43-319.
28. Salehi F., Dunfield L., Phillips K.P. et al. Risk Factors for Ovarian Cancer: an Overview with Emphasis on Hormonal Factors. J. Toxicol. Environ Health. 2008 ; 11 (3-4) : 301-321. DOI : https://doi.org/10.1080/10937400701876095
29. Vabre P., Gatimel N., Moreau J. et al. Environmental Pollutants, a Possible Etiology for Premature Ovarian Insufficiency: a Narrative Review of Animal and Human Data. Environ Health. 2017 ; 16 (1) : 37. DOI : https://doi.org/10.1186/s12940-017-0242-4
30. IARC. Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 109: Outdoor Air Pollution. Lyon, France: International Agency for Research on Cancer; 2016. URL: http://monographs.iarc.fr/ENG/Monographs/vol109/mono109. pdf
31. IARC. Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 100F: Chemical Agents and Related Occupations. Lyon, France: International Agency for Research on Cancer; 2012. URL : http://monographs.iarc.fr/ENG/Monographs/vol100F/ mono100F.pdf.
32. Andersen Z.J., Stafoggia M., Weinmayr G. et al. Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project. Environ. Health Perspect. 2017 ; 125 : 107005. DOI : https://doi.org/10.1289/EHP1742
33. Crouse D. L., Goldberg M. S., Ross N. A. et al. Postmenopausal Breast Cancer Is Associated with Exposure to Traffic-Related Air Pollution in Montreal, Canada: A CaseControl Study. Environ Health Perspect. 2010 ; 118 (11) : 1578-1583. DOI : https://doi.org/10.1289/ehp.1002221
34. Muzalov V.I., Tanzha O.B., Makovetska L.I. and Mykhailenko V.M. Porushennia pro-antyoksydantnoho balansu yak mekhanizm vynyknennia henotoksychnykh poshkodzhen v orhanizmi za poiednanoi dii ekzohennykh oksydiv azotu ta malykh doz ionizuiuchoi radiatsii pry pukhlynnomu rosti [Violation of Pro-Antioxidant Balance as a Mechanism of Genotoxic Damage in the Organism at the Combined Effect of Exogenous Nitrogen Oxides and Small Doses of Ionizing Radiation during Tumor Growth]. Dovkillia ta zdorovia. (Environment & Health). 2013 ; 4 : 8-13 (in Ukrainian).
35. Benedetti M., Zona A., Beccaloni E., Carere M., Comba P. et al. Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties. Int. J. Environ. Res. Public Health. 2017 ; 14 (4) : 355-366. DOI : https://doi.org/10.3390/ijerph14040355
36. IARC Monographs on the Evaluation of Carcinogenic Ricks to Humans, Volume 100: Arsenic, Metals, Fibres and Dusts. Lyon, France: IARC; 2012 : P. 219-309.
37. Leposhkina T.R. Navkolyshnie seredovyshche i reproduktyvne zdorovia silskykh zhinok [Environment and Reproductive Health of Rural Women]. Dovkillia ta zdorovia. (Environment & Health). 2004 ; 1 : 76-80 (in Ukrainian).
38. Nasiadek M., Krawczyk T. and Sapota A. Tissue Levels of Cadmium and Trace Elements in Patients with Myoma and Uterine Cancer. Hum. Exp. Toxicol. 2005 ; 24 (12) : 623-630. DOI : https://doi.org/10.1191/0960327105ht575oa
39. Jarup L. and Akesso A. Current Status of Cadmium as an Environmental Health Problem. Toxicol. Appl. Pharmacol. 2009 ; 238 (3) : 201-208. DOI : https://doi.org/10.1016/j.taap.2009.04.020
40. Del Pup L., Mantovani A., Cavaliere C. et al. Carcinogenetic Mechanisms of Endocrine Disruptors in Female Cancers (Review). Oncol. Rep. 2016 ; 36 (2) : 603-612. 41. Garcia E., Hurley S., Nelson D.O. et al. Hazardous Air Pollutants and Breast Cancer Risk in California Teachers: a Cohort Study. Environ. Health. 2015 ; 14 : 14. 42. Zhang X. and Ho S.M. Epigenetics Meets Endocrinology. J Mol Endocrinol. 2011 ; 46 (1) : 11-32. DOI : https://doi.org/10.1677/JME-10-0053
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