Environment & Health | ISSN: 2077-7477 eISSN: 2077-7485 |
No: 2 (87) - June, 2018 - Pages: 10-15
MTHFR:677TT genotype and hyperhomocyste - inemia in children from areas affected by the Chоrnobyl nuclear power plant accident
Bandazhevskyi Yu.I.1, Dubova N.F.2
1 Ecology and Health Coordination and Analytical Centre, Ivankov 2 P. L. Shupyk National Medical Academy for Post-Graduate Education, Kyiv
УДК: 616-008.9:577.112.386]-008.61-001.28-053.2-06:575.191]-02:614.73:
614.876.004.6(477)
SUMMАRY:
TT homozygous variant of MTHFR: С677T genetic polymorphism is associated with almost full loss of methylene tetrahydrofolatreductasa, the main enzyme of folate cycle. A degree of the manifestation of genetic polymorphism is connected with the external impact. Objective. We determined the phenotypical manifestation of MTHFR: С677T genotype in the groups of the children from the regions, contaminated with the radioactive agents as a result of the accident of the Chornobyl nuclear power plant and having a different level of social-and-economic development, using the parameters of the content of homocystein in blood and frequencies of the occurrence of the state of hyperhomocysteinemia. Methods: immunochemical, mathematical-andstatistical. Results. In the subgroup of the children-carriers of MTHFR:677ТT genotype, suffered from the accident at the Chornobyl nuclear power plant, a content of homocystein in blood was authentically larger in comparison with the subgroups of the children that were not the carrier of given genotype. The presence of risk allele of MTHFR:677ТT Т polymorphism predetermines the elevated homocystein formation in the children residing at the territory, contaminated with radioactive elements as a result of the accident at the Chornobyl nuclear power plant, in comparison with the children not having МTHFR:677ТT genotype in the content of their genome. Phenotypic manifestation of MTHFR:677ТT genome as elevated formation of homocystein in the organism (state of hyperhomocysteinemia) is more expressed in the children from the regions that are in worse social-and-economic conditions after the accident at the Chornobyl nuclear power plant.
KEYWORDS:
hyperhomocysteinemia, MTHFR:677TТ genotype, polymorphisms of folate cycle, T risk allele, areas contaminated with radionuclides, accident at the Chornobyl nuclear power plant, children.
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