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1 (90), 2019


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 2 (87)   -   June, 2018   -   Pages: 10-15
MTHFR:677TT genotype and hyperhomocyste - inemia in children from areas affected by the Chrnobyl nuclear power plant accident
Bandazhevskyi Yu.I.1, Dubova N.F.2
1 Ecology and Health Coordination and Analytical Centre, Ivankov
2 National Medical Academy of Postgraduate Education named after P.L. Shupyk, Ministry of Health of Ukraine, Kyiv

: 616-008.9:577.112.386]-008.61-001.28-053.2-06:575.191]-02:614.73: 614.876.004.6(477)

SUMMRY:
TT homozygous variant of MTHFR: 677T genetic polymorphism is associated with almost full loss of methylene tetrahydrofolatreductasa, the main enzyme of folate cycle. A degree of the manifestation of genetic polymorphism is connected with the external impact. Objective. We determined the phenotypical manifestation of MTHFR: 677T genotype in the groups of the children from the regions, contaminated with the radioactive agents as a result of the accident of the Chornobyl nuclear power plant and having a different level of social-and-economic development, using the parameters of the content of homocystein in blood and frequencies of the occurrence of the state of hyperhomocysteinemia. Methods: immunochemical, mathematical-andstatistical. Results. In the subgroup of the children-carriers of MTHFR:677T genotype, suffered from the accident at the Chornobyl nuclear power plant, a content of homocystein in blood was authentically larger in comparison with the subgroups of the children that were not the carrier of given genotype. The presence of risk allele of MTHFR:677T polymorphism predetermines the elevated homocystein formation in the children residing at the territory, contaminated with radioactive elements as a result of the accident at the Chornobyl nuclear power plant, in comparison with the children not having THFR:677T genotype in the content of their genome. Phenotypic manifestation of MTHFR:677T genome as elevated formation of homocystein in the organism (state of hyperhomocysteinemia) is more expressed in the children from the regions that are in worse social-and-economic conditions after the accident at the Chornobyl nuclear power plant.

KEYWORDS:
hyperhomocysteinemia, MTHFR:677T genotype, polymorphisms of folate cycle, T risk allele, areas contaminated with radionuclides, accident at the Chornobyl nuclear power plant, children.
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