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2 (87), 2018


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 2 (87)   -   2018   -   Pages: 10
MTHFR:677TT genotype and hyperhomocyste - inemia in children from areas affected by the Chrnobyl nuclear power plant accident
BANDAZHEVSKYI Yu.I., DUBOVA N.F.

SUMMERY:
TT homozygous variant of MTHFR: 677T genetic
polymorphism is associated with almost full loss of
methylene tetrahydrofolatreductasa, the main
enzyme of folate cycle. A degree of the manifestation
of genetic polymorphism is connected with the
external impact.
Objective. We determined the phenotypical
manifestation of MTHFR: 677T genotype in the
groups of the children from the regions, contaminated
with the radioactive agents as a result of the
accident of the Chornobyl nuclear power plant and
having a different level of social-and-economic
development, using the parameters of the content
of homocystein in blood and frequencies of the
occurrence of the state of hyperhomocysteinemia.
Methods: immunochemical, mathematical-andstatistical.
Results. In the subgroup of the children-carriers of
MTHFR:677T genotype, suffered from the accident
at the Chornobyl nuclear power plant, a content
of homocystein in blood was authentically larger
in comparison with the subgroups of the children
that were not the carrier of given genotype.
The presence of risk allele of MTHFR:677T
polymorphism predetermines the elevated
homocystein formation in the children residing
at the territory, contaminated with radioactive
elements as a result of the accident at the
Chornobyl nuclear power plant, in comparison
with the children not having THFR:677T genotype
in the content of their genome.
Phenotypic manifestation of MTHFR:677T
genome as elevated formation of homocystein
in the organism (state of hyperhomocysteinemia)
is more expressed in the children from the regions
that are in worse social-and-economic conditions
after the accident at the Chornobyl nuclear
power plant.

KEYWORDS:
hyperhomocysteinemia, MTHFR:677T genotype, polymorphisms of folate cycle, T risk allele, areas contaminated with radionuclides, accident at the Chornobyl nuclear power plant, children.
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