Home Page   -   ditorial Board   -   Instructions to autors   -   Archive   -   Contact   -   Journal's Indexing UA   EN

Last issue

2 (91), 2019


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 2 (87)   -   June, 2018   -   Pages: 15-18
Allelic polymorphism of the genes of dna reparation and likelihood of bronchopulmonary pathology development in miners and workers of asbestos cement plants in Ukraine
Andrushchenko .A.1
1 SI " Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine "

: [575.113: 577.21 : [622+666.961. 006.3] 057 (477)

The results of the research on the polymorphism of DNA reparation genes in miners and workers of asbestos cement plants with the occupationally determined respiratory pathology are presented in the article.

Objective: We studied the distribution of the genotype frequencies of XRCC1 (rs25487) and XRCC3 (rs861539) genes in miners and workers of asbestos cement plants for the identification of the markers of the risk of the development of bronchopulmonary pathology.

Materials and methods: The workers of asbestos-cement plants and miners were engaged in the study. The real-time polymerase chain reaction was used to determine the genotypes of DNA reparation genes.

Results: It was established that the XRCC1*AA genotype was associated with the risk of bronchopulmonary pathology in the population of workers of the asbestos-cement plants and miners of Ukraine. The protective role of the genotype XRCC1*GA in relation to the risk of developing bronchopulmonary system diseases in workers of asbestos-cement plants in Ukraine has been established.

molecular-and-genetic markers, XRCC1, XRCC3, bronchopulmonary pathology
1. Izmerov N.F. and Chuchalin A.G. (eds.) Professionalnye zabolevaniya organov dykhaniya (Natsionalnoe rukovodstvo) [Occupational Diseases of Respiratory Organs (National Guide)]. Moscow : GEOTAR-dia; 2015 : 119-148 (in Russian).
2. Kuzmina L.P. Biokhimicheskie I geneticheskie pokazateli individualnoi chuvstvitelnosti k professionalnym vrednostiam [Biochemical and Genetic Parameters of Individual Sensitivity to the Occupational Hazards]. In : Professionalnyi risk dlia zdorovia rabotnikov (rukovodstvo) [Occupational Risk to the Health of the Workers (Guide)]. N.F. Izmerov and E.N. Denisov (eds.). scow : Trovant ; 2003 : 329-334 (in Russian).
3. Hao B., Miao X., Li Y., Zhang X., Sun T. et al. Oncogene. 2006 ; 25 : 36133620. https://doi.org/10.1038/sj.onc.1209355
4. Kubota Y., Nash R.A., Klungland A., Schär P., Barnes D.E. and Lindahl T. EMBO J. 1996 ; 15 : 66626670. https://doi.org/10.1002/j.1460-2075.1996.tb01056.x
5. Kuschel B., Auranen A., McBride S., Novik K.L., Antoniou A. et al. Hum Mol Genet. 2002 ; 11 : 13991440. https://doi.org/10.1093/hmg/11.12.1399
6. Pavanello S. and Clonfero E. G Ital Med Lav Ergon. 2004 ; 26 (4) : 311-321 (in Italian).
7. Rodriguez S., Gaunt T.R. and Day I.N.M. American Journal of Biological Epidemiology. 2009 ; 169 (4) : 505514. DOI 10.1093/aje/kwn359. https://doi.org/10.1093/aje/kwn359
8. Shin A., Lee K.M., Ahn B., Park C.G., Noh S.K. et al. Asian Pac J Cancer Prev. 2008 ; 9 : 501505.
9. Tebbs R.S., Zhao Y., Tucker J.D., Scheerer J.B., Siciliano M.J. et al. Proc Natl Acad Sci USA. 1995 ; 92 : 63546358. https://doi.org/10.1073/pnas.92.14.6354
10. Thacker J. and Zdzienicka M.Z. DNA Repair (Amst.). 2004 ; 3 : 10811090. https://doi.org/10.1016/j.dnarep.2004.04.012
11. Wang Y., Yang H., Li H., Li L., Wang H., Liu C. and Zheng Y. Cancer Lett. 2009 ; 285 : 134140. https://doi.org/10.1016/j.canlet.2009.05.005
12. Zienolddiny S., Campa D., Lind H., Ryberg D., Skaug V., Stangeland L., Phillips D.H., Canzian F. and Haugen A. Carcinogenesis. 2006. Vol. 27. 3. P. 560567.
Designed by: IPH NAMSU Environment & Health, 2006-2019. All rights reserved.
Use of text and graphic materials of the site is allowed only upon written permission of the editoral board.