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4 (101), 2021


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 4 (101)   -   December, 2021   -   Pages: 11-18
Homocysteine, pituitary and thyroid hormones in children with different physical growth levels after forest fires in the Chernobyl exclusion zone
Bandazhevskyi Yu. I.1, Dubova N. F.2
1 Ecology and Health Coordination and Analytical Centre, Ivankov
2 Shupyk National Healthcare University of Ukraine

ABSTRACT:
Objective We performed a comparative assessment of the blood levels of homocysteine, pituitary and thyroid hormones in children with different levels of physical development before and after forest fires in the Chornobyl exclusion zone (ChEZ) in 2015.

Methods: We used immunochemical, instrumental, mathematical and statistical methods.

Results: The analysis of variable dynamics was performed in 336 adolescents of the Polisskyi and the Ivankivskyi districts of Kyiv region. An association was found between homocysteine (), hormones of the pituitary-thyroid axis and physical development of children. A statistically significantly higher level of was observed in the adolescents from the Ivankivskyi district in comparison with the children from the Polisskyi district. Forest fires in the spring and summer of 2015 in the ChEZ should be considered the main cause for the increase in in the blood of the adolescents. The increased level of 3 in the peripheral tissues induced by y and TSH contributed to a decrease in the physical development index values. Due to a decrease in the intensity of the 4 deiodination process, the insufficient formation of 3 in the peripheral tissues was recorded in the group of children with a disharmonious high physical development.

KEYWORDS:
homocysteine, hypophysis and thyroid gland hormones, physical development , adolescents, forest fires, Chornobyl exclusion zone.
REFERENCES:
1. Bandazhevskyi Yu.I. and Dubova N.F. omparative Assessment of Metabolic Processes in Children Living in the Areas Affected by the Chernobyl Nuclear Power Plant Accident. Environment&Health. 2017 ; 4 : 27-30. DOI : https://doi.org/10.32402/dovkil2017.04.027
2. McCully K.S. Homocysteine and the Pathogenesis of Atherosclerosis. Expert Review of Clinical Pharmacology. 2015 ; 8(2) : 211-219. DOI : https://doi.org/10.1586/17512433.2015.1010516
3. Keshteli A., Baracos V. and Madsen K. Hyperhomocysteinemia as a Potential Contributor of Colorectal Cancer Development in Inflammatory Bowel Diseases: A Review. World J Gastroenterol. 2015 ; 21(4) : 10811090. DOI : https://doi.org/10.3748/wjg.v21.i4.1081
4. Kashparov V.A., Mironyuk V.V., Zhurba M.A. et al. Radiologicheskiye posledstviya pozhara v Chernobylskoy zone otchuzhdeniya v aprele 2015 goda [Radiological Consequences of the Fire in the Chernobyl Exclusion Zone in April, 2015]. Radiatsionnaya biologiya. Radioekologiya. 2017 ; 57 (5) : 512-527 (in Russian).
5. Labunska I., Levchuk S., Kashparov V. et al. Current Radiological Situation in Areas of Ukraine Contaminated by the Chornobyl Accident: Part 2. Strontium-90 Transfer to Culinary Grains and Forest Woods from Soils of Ivankiv District. Environment International. 2021 ; 146 : 106282. https://doi. org/10.1016/j.envint.2020.106282
6. Zahalnodozymetrychna pasportyzatsiia ta rezultaty LVL-monitorynhu v naselenykh punktakh Ukrainy, yaki zaznaly radioaktyvnoho zabrudnennia pislia Chornobylskoi katastrofy. Dani za 2011 r. [General Dosimetric Certification and Results of WBC-Monitoring in the Settlements of Ukraine Suffered from the Radioactive Contamination after Chornobyl Catastrophe]. yiv ; 2012; Iss. 14 : 99 . (in Ukrainian).
7. Serdiuk A.M. (Ed.). Standarty dlia otsinky fizychnoho rozvytku shkoliariv [Standards for the Assessment of the Physical Development of the Schoolchildren]. Iss. 3. Kyiv : Kazka ; 2010 : 60 p. (in Ukrainian).
8. Baranov A.A., Kuchma V.R., Yampolskaya Yu.A. et al. Metody issledovaniya fizicheskogo razvitiya detey i podrostkov v populyatsionnom monitoringe : rukovodstvo dlya vrachey [Methods for the Study of the Physical Development of Children and Adolescents in the Population Monitoring: Guide for Doctors]. Moscow ; 1999 : 226 p. (in Russian).
9. Ivakhno O.P., Koziarin I.P. and Niemtseva Yu.V. Metody otsinky fizychnoho rozvytku i zdorovia dytiachoho naselennia : Navchalnyi posibnyk [Methods for the Assessment of Physical Development and Health of the Childrens Population: Textbook]. Kyiv ; 2012 : 129 p. (in Ukrainian).
10. Bandazhevsky Yu.I. and Dubovaya N.F. Physical Development of Children in the Presence of 137Cs Incorporation 30 Years after the Chernobyl Nuclear Power Plant Accident. Collection of Scientific and Practical Articles Chernobyl: Ecology and Health: Under general editorship of Prof. Yu.I. Bandazhevsky.- Issue 9. Ivankov : PI Coordination and Analytical Center Ecology and Health ; Dnipro: Seredniak .. ; 2019 : 29-41.
11. Kubarko A.I. and Yamashita S. (eds.). Shchitovidnaya zheleza. Fundamentalnyye aspekty [Thyroid Gland. Fundamental Aspects]. Minsk - Nagasaki ; 1998 ; 368 p. (in Russian).
12. Bandazhevsky Yu.I. and Dubovaya N.F. The Role of Folate Metabolism Genome in the Formation of Triiodothyronine in Children Living in Areas Affected by the Chernobyl Nuclear Power Plant Accident. In : Faktory eksperymentalnoi evoliutsii orhanizmiv : zb. nauk. pr. [Factors of Experimental Evolution of Organism: Coll. Sci. Works ]. Kyiv ; 2019 ; 24 : 197-201. https://doi.org/10.7124/FEEO.v24.1101
13. Bandazhevskyi Yu.I. and Dubova N.F. Comparative Assessment of Blood Levels of Homocysteine, Hormones and Minerals in Children with Different Levels of Physical Development Living Near the Chornobyl Exclusion Zone. Environment&Health. 2021 ; 2(99) : 28-35. DOI: https://doi.org/10.32402/dovkil2021.02.028
14. Bandazhevskiy Yu.I. and Dubovaya N.F. Laboratornyy skrining v diagnostike sostoyaniy shchitovidnoy zhelezy u detey iz radioaktivno zagryaznennykh rayonov spustya 30 let posle avarii na Chernobylskoy atomnoy elektrostantsii [Laboratory Screening in the Diagnosis of Thyroid Gland State in Children from Radioactively Contaminated Areas after 30 Years of the Accident at the Chernobyl Nuclear Power Plant]. Zbirnyk naukovykh prats spivrobitnykiv NMAPO imeni P.L. Shupyka [Collection of Scientific Works of the Staff Members of P. L. Shupyk NMAPE]. Kyiv ; 2016 ; 26 : 494-499 (in Russian).
15. Park S.K., ONeill M.S., Vokonas P.S. et al. Traffic-Related Particles Are Associated with Elevated Homocysteine. The VA Normative Aging Study. Am. J. Respir. Crit. Care Med. 2008 ; 178 : 283289. DOI: https://doi.org/10.1164/rccm.200708-1286OC
16. Sheybak V.M., Lelevich V.V. and Bandazhevsky Yu.I. Free Amino Acids of Blood Plasma and Tissues of Animals after Incorporation of Cesium and Strontium Radionuclides. In : Clinical and Experimental Aspects of the Effect of Incorporated Radionuclides upon the Organism. Bandazhevsky Yu.I. and Lelevich V.V. (eds.). Gomel, Belarus ; 1995 : 83-106.
17. Bandazhevsky Yu.I. and Dubovaya N.F. Forest Fires in the Chernobyl Exclusion Zone and Childrens Health. Coordination and Analytical Center Ecology and Health. Kyiv : Aliant LLC ; 2021 : 44 p.
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