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3 (100), 2021


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 3 (79)   -   2016   -   Pages: 4-9
omparative assessment of the toxicological properties of amphoteric surfactants
Yalovenko O.I.1, Golichenkov .M.1, Raietska O.V.1, Liashenko V.I.1, Maistrenko Z.Yu.1, Umanets H.P.1, Kucherenko O.Yu.1, Babii V.F.1, Kondratenko O.Ye.1, Pimushyna M.V.1, Vinarska O.I.1, Hryhorenko L.Ye.1, Moldavska N.B.1, Tomashevska L.A.1, Didyk N.V., Lemeshko L.P.1
1 State Institution "O.M. Marzeiev Institute for Public Health of the NAMSU"

: 543.395 : 661.185.3 : 615.9

ABSTRACT:
Objective. We performed a comparative study of the toxicological properties of different amphoteric surfactants for the prognostication of their harmful effect at the use of a cosmetic cleanser in the composition.

Materials and methods. Four amphoteric surfactants: Cocoamphodiacetate, Coco-betain, Cocamodopropyl Betaine, Sodium Cocoyl Glutamate were studied in the work. Research was performed by the method of the in vitro assessment of cytotoxicity; classic toxicological method of the determination of toxicity integral indices; study of transdermal effect of the surfactants on guinea-pigs during 4 months with the assessment of hematological, immunological and biochemical indices of blood.

Results and onclusions. We experimentally proved that all studied amphoteric surfactants had cytotoxic and dermaresorptive properties of different degrees. Immunotoxic effect (suppression and sensibilization) was determined to be a characteristic feature of the biological effect of the amphoteric surfactants at their transdermal effect. Cocamodopropyl Betaine was the most toxic, it is a single among studied amphoteric surfactants to cause a development of hypersensitiveness of immediate and delayed types. Cocoamphodiacetate and Sodium Cocoyl Glutamate are the most safe. Their resorptive effect was proved by immunotoxic effect only.

KEYWORDS:
amphoteric surfactants, in vitro, in vivo methods, cytotoxic, immunotoxic, absorption, sensitization.
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