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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 4 (84)   -   2017   -   Pages: 27-30
Comparative assessment of metabolic processes in children living in the areas affected by the hernobyl nuclear power plant accident
Bandazhevskyi Yu.I.1, Dubova N.F.2
1 Ecology and Health Coordination and Analytical Centre, Ivankiv
2 National P.L. Shupyk Medical Academy of Postgraduate Education, Kyiv

: 616-008.9-001.28-053.6/.7 : 613.2-06:613.956/.96 : 612.015.3/.6 : 614.876 : 621.039.004.6

ABSTRACT:
Objective: We performed a comparative assessment of metabolic processes in the children living for a long time in Polissia and Ivankiv districts of Kyiv oblast, at the territories contaminated with radioactive elements as a result of the accident at the Chornobyl NPP.

Materials and methods: We determined a content of 137Cs radionuclides, a content of thyrotropic pituitary hormones, triiodothyronine, thyroxin, homocysteine, vitamins B9, B12 in the blood of the adolescents, and a state of folate metabolism genetic system as well.The immunochemical and mathematical-and-statistical methods were applied.

Results: The percentage of the children in the age group under study with 137Cs concentration in the organism over 5 Bq/kg of body weight was 34.1 % in Polissia district and was significantly higher (p<0.05) than in Ivankiv district - 14.4 %. The genome of folate metabolism didnt have significant differences in the children of both districts. There were no risk alleles of folate metabolism genetic polymorphisms in 3.2 % of the cases in the group of the children from Polissia district and in 1.1 % in the group of the children from Ivankiv district. A level of homocystenia exceeded a physiological criterion (state of hyperhomocysteinemia) in 79.8 % of cases in the group of the children from Polissia district and in 73.2 % of cases in the group of the children from Ivankiv district.A content of folic acid and thyroxine in the blood was significantly lower in the group of children from Polissia district than in Ivankiv district.

Conclusions: The poor socio-economic conditions are the reasons for a higher content of radionuclides, hyperhomocysteinemia, disruption of the production of thyroid gland hormones, deficiency of folic acid and vitamin B12 in the children from Polissia district in comparison with the children from Ivankiv district. The incorporation of 137Cs radionuclides in the organism and thyroid gland, and folic acid deficiency can lead to disruption of thyroxine production by the thyroid gland in the children living at the territory contaminated with radionuclides as a result of the accident at the Chornobyl NPP.

KEYWORDS:
homocysteine, folate metabolism, thyroid and pituitary hormones, folic acid, vitamin B12, adolescents, radiation-contaminated areas.
REFERENCES:
1. State Institution "National Research Centre for Radiation Medicine of NAMS of Ukraine" ; Radiation Protection Research Institute of the Academy of Technology Sciences of Ukraine. Zahalnodozymetrychna pasportyzatsiia ta rezultaty LVL-monitorynhu v naselenykh punktakh Ukrainy, yaki zaznaly radioaktyvnoho zabrudnennia pislia Chornobylskoi katastrofy. Dani za 2011 r. [General Dosimetric Certification and Results of WBC-Monitoring in the Settlements of Ukraine Suffered from the Radioactive Contamination after Chornobyl Catastrophe]. yiv ; 2012; Iss. 14 : 99 . (in Ukrainian).
2. Bandszhevskiy Yu.I. and Dubovaia N.F. Pediatriia. Vostochnaia Evropa. 2017 ; 5 (1) : 25-32 (in Russian).
3. Bandazhevskiy Yu.I. Swiss. Med. Weekly. 2003 ; 133 : 488-490.
4. Libanova .. Demohrafiia ta sotsialna ekonomika. 2011 ; 2 (16) : 3-18 (in Ukrainian). https://doi.org/10.15407/dse2011.02.003
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