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Ļ 4 (101), 2021


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 4 (101)   -   December, 2021   -   Pages: 27-33
Features of the immune response of the organism of the experementel animals to the exposure of the detergents based on anionic surfactans designed for the care of childrenís tableware
Holichenkov O.M.1, Hryhorenko L.Yu.1, Stepanchuk S.V.1, Domaratska Yu.S.1, Liashenko V.I.1, Maistrenko Z.Yu.1
1 State Institution "O.M. Marz≥eiev Institute for Public Health of the NAMSU", Kyiv

ABSTRACT:
Objective: We assessed the impact of the detergents, based on anionic surfactants, for the care of the childrenís tableware on the indicators of the immune system of the experimental animals.

Materials and methods: The effect of aqueous solutions of Alionka, Karapuz, Ushastyi Nian, Frosch Baby detergents on the indicators of the immune system was performed in the experiment with guinea pigs during 21 days. We determined the number of T- and B-lymphocytes, the number of neutrophilic granulocytes and active phagocytes; studied the reaction of the precipitation of circulating immune complexes with a solution of polyethylene glycol 6000. We used the methods of statistical processing of the results of medico-biological research.

Results: The obtained results showed that the epicutaneous impact of all studied detergents for the care of childrenís tableware could cause the immunomodulatory effects in the organism of guinea pigs. Changes in the largest number of the indicators of the immune system, which affected all links, were observed when exposed to Ushastyi Nian detergent. The least pronounced changes of the immunity were observed when exposed to the Frosch Baby detergent and they concerned only the indices of nonspecific resistance of the organism. The revealed inhibition of the functional activity of neutrophilic granulocytes, which was observed in animals of all experimental groups, may indicate a decrease in the protective functions of the organism of guinea pigs.

KEYWORDS:
detergents for care of childrenís tableware, anionic surfactants, indicators of immune system, experimental animals
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