|Environment & Health||ISSN: 2077-7477 eISSN: 2077-7485
No: 4 (97) - December, 2020 - Pages: 21-26
Hyperhomocysteinemia in children and forest fires in the ChÓrnobyl exclusion zone
Bandazhevsky Yu.I., Dubova N.F.1
1 P. L. Shupyk National Medical Academy for Post-Graduate Education, Kyiv
Objective: We determined a role of folate metabolism genotypes in the occurrence of hyperhomocysteinemia in children after a forest fire in the ChÓrnobyl exclusion zone (ChEZ).
Material and methods: In the study, we applied immunochemical, Real-time PCR, mathematical and statistical methods.
Results: A survey of 84 adolescents from the Poliske district, Kiev region revealed changes in their metabolic processes in the form of increased homocysteine production in connection with a forest fire in the ChEZ which was recorded during April 26-29, 2015. A comparative analysis of the specific gravity of the folate cycle genotypes in the subgroups of the children with hyperhomocysteinemia before and after a forest fire showed that an endogenous factor in the form of a genetic apparatus, controling synthesis of folate cycle enzymes, was not involved in this phenomenon.
—onclusions: Forest and peat fires in the Chernobyl exclusion zone are one of the main causes for the elevation in blood homocysteine levels in children from the adjacent districts, regardless of the state of folate metabolism genetic system. Monitoring of the blood homocysteine levels in children and adults living under conditions of the exposure to wood combustion gases, containing radioactive elements, is a key component of the programmer for the prevention of cancer and cardiovascular diseases.
folate metabolism, homocysteine, adolescents, forest fires, ChÓrnobyl exclusion zone.
1. Bandazhevski Yu.I. and Dubovaya N.F. Folate Metabolism Gene Polymorphisms and Homocysteinemia in Children from Families Continuously Living in an Area Affected by the ChÓrnobyl Nuclear Power Plant Accident. Collection of Scientific and Practical Articles ęChernobyl: Ecology and HealthĽ. Yu.≤. Bandazhevsky (Ed.). ≤ssue3. Ivankov ; Dnipropetrovsk ; 2015 : 16-25.
2. Lentz S.R. and Haynes W.G. Homocysteine: is it a Clinically Important Cardiovascular Risk Factor? Clin. J. Med. 2004 ; 71 : 729-734.
3. Bandazhevsky Yu.I. and Dubova N.F. Assessment of Folate Metabolism Functioning in Terms of Prevention of Breast Cancer in the Population Living in Areas Affected by the Chernobyl Nuclear Power Plant Accident. Collection of Scientific Works of Staff Members of NMAPE. 2017 ; 27 : 215-225.
4. Bandazhevskyi Yu.I. and Dubova N.F. MTHFR:677““ Genotype and State of Hyperhomocysteinemia in the Children of Regions Suffered as a Result of the Accident at the —hÓrnobyl Nuclear Power Plant. Dovkillia ta zdorovia (Environment & Health). 2018 ; 2 (86) : 10-15. DOI : https://doi.org/10.32402/dovkil2018.02.010
5. Kolpakova A.F., Sharipov R.N. and Volkova O.A. Vliyaniye zagryazneniya atmosfernogo vozdukha vzveshennymi veshchestvami na serdechno-sosudistuyu sistemu [Impact of Ambient Air Pollution with Suspended Particles on Cardiovascular System]. Sibirskiy meditsinskiy zhurnal. 2015 ; 30 (3) : 7-12 (in Russian).
6. Pope C.A., Turner M.C., Burnett R. et al. Relationships between Fine Particulate Air Pollution, Cardiometabolic Disorders and Cardiovascular Mortality. Circ. Res. 2015 ; 116 (1) : 108-115. DOI : https://doi.org/10.1161/CIRCRESAHA.116.305060
7. Park S.K., OíNeill M.S., Vokonas P.S. et al. Traffic Related Particles are Associated with Elevated Homocysteine. The VA Normative Aging Study. Am. J. Respir. Crit. Care Med. 2008 ; 178 : 283-289. DOI : https://doi.org/10.1164/rccm.200708-1286OC
8. Kashparov V.A., Mironyuk V.V., Zhurba M.A. et al. Radiologicheskiye posledstviya pozhara v Chernobylskoy zone otchuzhdeniya v aprele 2015 goda [Radiological Consequences of the Fire in the Chernobyl Exclusion Zone in April 2015]. Radiatsionnaya biologiya. Radioekologiya. 2017 ; 57 (5) : 512-527 (in Russian). DOI : https://doi.org/10.7868/S0869803117050071
9. Zahalnodozymetrychna pasportyzatsiia ta rezultaty LVL-monitorynhu v naselenykh punktakh Ukrainy, yaki zaznaly radioaktyvnoho zabrudnennia pislia Chornobylskoi katastrofy. Dani za 2011 r. Zbirka 14 [General Dosimetric Certification and Results of HIC-Monitoring in the Settlements of Ukraine Affected the Radioactive Contamination after the Chornobyl Disaster. Data for 2011]. Kyiv : Ministry of Health of Ukraine; 2012 : 99p. (in Ukrainian).
10. Bogorad V.I., Litvinskaya T.V., Shevchenko I.A., Dybach A.M. and Slepchenko A.Yu. Radiatsionnyye posledstviya pozhara v zone otchuzhdeniya Chernobylskoy AES [Radiation Consequences of the Fire in the Chernobyl Exclusion Zone]. Yaderna ta Radiatsiina Bezpeka. 2016 ; 69 (1) : 64-68 (in Russian). DOI : https://doi.org/10.32918/nrs.2016.1(69).10
11. Ren C., Park S., Vokonas P., Sparrow D. et al. Air Pollution and Homocysteine: More Evidence that Oxidative Stress-related Genes Modify Effects of Particulate Air Pollution. Epidemiology. 2010 ; 21 (2) : 198-206.
12. Bandazhevskůi Yu.I., Dubovaya N.F., Bandazhevskaya G.S. et al. Assessment of the Cardiovascular System in Children from Polesie and Ivankov Districts. Collection of Scientific and Practical Articles ęChÓrnobyl: Ecology and HealthĽ. Yu.≤. Bandazhevsky≥ (Ed). ≤ssue 2. Ivank≥v; Dnipropetrovsk; 2015 : 22-35.
13. Sheybak V.M., Lelevich V.V. and Bandazhevsky≥ Yu.I. Svobodnyye aminokisloty plazmy krovi i tkaney zhivotnykh posle inkorporatsii radionuklidov tseziya i strontsiya [Free Amino Acids of Blood Plasma and Animal Tissues after Incorporation of Cesium and Strontium Radionuclides]. In : Kliniko-eksperimentalnyye aspekty vliyaniya inkorporirovannykh radionuklidov naorganism [Clinical-and-Experimental Aspects of the Effect of Incorporated Radionuclides on the Organism]. Bandazhevsky≥ Yu.I. and Lelevich V.V. (Eds.). Gomel (Belarus) ; 1995 :101-127 (in Russian).