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4 (93), 2019


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 3 (92)   -   September, 2019   -   Pages: 61-68
Influence of natural and man-made factors on the function of thyroid gland (literature review)
Korzun V.N.1, Vorontsova T.O.2
1 State Institution "O.M. Marzeiev Institute for Public Health of the NAMSU"
2 Ternopil I.Ya. Gorbachevskyi State Medical University, Ministry of Health of Ukraine

: 614.7 : 612.44: 613.27

SUMMRY:
Analysis of the scientific publications confirmed a significant influence of medico-social, hygienic, and environmental factors on the epidemiology of iodine deficiency diseases and as well as an absence of the direct dependence of thyroid pathology on the degree of iodine deficiency. Ecological factors (pollution of air, water, and soil with heavy metals, pesticides, fertilizers, radioactive isotopes) significantly affect the occurence and prevalence of thyroid gland diseases. The long-term effect of the factors, exhibiting the goitrogenic effect, increases the iodine deficiency, significantly affects the iodine-thyroid state and functioning of thyroid gland, and leads to an increase in the incidence of thyroid pathology, especially in goiter endemic areas.

However, the growth of morbidity in the iodine deficiency non-endemic regions of Ukraine shows that iodine deficiency is not a prior factor in the genesis of diffuse nontoxic goiter, and the cause of the disorders is in a numerical imbalance of microelements.

Both natural and anthropogenic environmental factors were established to affect the occurence and course of thyroid disease, but none of these factors is isolated, they operate in a complex, accumulating on the social and hereditary factors. The occurrence and prevalence of goiter is a result of the complex interaction of endogenous and numerous exogenous factors, including those related to human activity. Goiter is a multifactorial disease and can be an indicator of the environmental disadvantage of the settlements.

To understand the problem of iodine deficiency and to develop more effective approaches to the treatment of the patients with iodine deficiency, the doctors and the scientists should conduct a systematic analysis of the relationships between iodine metabolism, thyroid function and some microelements on the basis of the data of physiology, biochemistry, molecular biology, pharmacology, food hygiene, and evidence-based medicine.

KEYWORDS:
Thyroid gland, iodine deficiency diseases, goitrogenic factors, deficiency of microelements
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