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Environment & Health | ISSN: 2077-7477 eISSN: 2077-7485 |
No: 4 (113) - December, 2024 - Pages: 60-64
Microbiological spectrum of causative agents of healthcare-associated infections isolated in Ukraine in 2022-2023
Rosada M.O.1, Hlushkevych T.G.1, Sboieva A.M.1, Surmasheva O.V.2, Molchanets O.V.2
1 SI «Public Health Center of the Ministry of Health of Ukraine», Kyiv, Ukraine 2 State Institution "O.M. Marz³eiev Institute for Public Health of the NAMSU", Kyiv
ÓÄÊ: 579.6:616-94/95:616.01
ABSTRACT:
The purpose of the study is to identify strains of microorganisms, pathogens of infections associated with the provision of medical care, isolated from patients in Ukraine in 2022-2023.
Research materials and methods: Strains of microorganisms that came to the Reference Laboratory for the diagnosis of tuberculosis, bacterial, parasitic and especially dangerous pathogens of the Public Health Center of the Ministry of Health of Ukraine from the regional centers of disease control and prevention and health care institutions of Ukraine were studied. Microorganisms were identified using the VITEK 2 microbiological analyzer, MIC Test strips. 1454 versus 343 strains isolated in 2022 were analyzed using the WHONET computer program.
Research results: In 2023, the number of cultures of opportunistic microorganisms, the probable causative agents of infections associated with the provision of medical care, increased more than 4 times. 1471 cultures were obtained against 358 in 2022. The largest number of strains came from healthcare facilities in Kyiv (22.4%), Dnipropetrovsk (14.4%), Lviv (11.6%), Khmelnytskyi (10.7%), Zaporizhia (8.2% ), Odesa (4.8%), Rivne (3.9%), Ivano-Frankivsk (3.7%), Cherkasy (2.5%), Zakarpattia (2.5%), Kirovohrad (2.2% ) regions. The specific weight of other regions of Ukraine, where crops came from, excluding those where active hostilities are taking place (Donetsk, Luhansk, Kherson regions), ranged from 0.4% to 1.8%. Among the studied cultures, gram-negative microorganisms dominated - 92%, gram-positive - 8%. K .pneumoniae - 35.2% (30.6%); A. baumannii - 26.0% (19.0%); P. aeruginosa - 19.9% (19.2%); E. coli - 5.3% (15.2%); E. cloacae - 2.3% (7.3%); P. mirabilis - 1.5% (1.7%); S. aureus - 4.5% (1.7%); S. epidermidis - 1.2% (0.9%); S. haemolyticus - 1.1% (1.5%); E. faecalis - 0.6% (0.3%); E. faecium - 0.6% (2.0%); others - 1.8% (0.6%). According to the place of localization, culture strains were isolated: from wounds - 1045 cultures - 71.9% (45.5%), from blood - 263 cultures - 18.1% (20.7%), from cerebrospinal fluid (SMR) - 52 cultures - 3.6% (3.2%), from urine - 82 cultures - 5.6% (26.2%), from the external environment (ZS) - 12 cultures - 0.8% (4.4%).
CONCLUSIONS 1. Based on the results of the microbiological analysis, the etiological structure of the pathogens of infections associated with the provision of medical care in Ukraine for 2022-2023 was determined. 2. In 2023, the number of cultures of opportunistic pathogens, the probable causative agents of infections associated with the provision of medical care, received by the Public Health Center of the Ministry of Health of Ukraine increased by more than 4 times, 1471 cultures were obtained against 358 in in 2022. 3. The largest number of strains came from healthcare facilities in Kyiv (22.4%), Dnipropetrovsk (14.4%), Lviv (11.6%), Khmelnytskyi (10.7%), Zaporizhia (8.2%), 4. The microbial landscape of the sent cultures is represented by the most widespread microorganisms that are subject to sentinel epidemiological surveillance of antimicrobial resistance in Ukraine. Among the studied cultures, gram-negative microorganisms dominated - 92%, gram-positive - 8%.
KEYWORDS:
bacteria, healthcare-associated infections, epidemiological surveillance
REFERENCES:
1. Avershina E, Shapovalova V, Shipulin G. Fighting antibiotic resistance in hospital-acquired infections: current state and emerging technologies in disease prevention, diagnostics and therapy. Frontiers in Microbiology. 2021 Jul 21;12. https://doi.org/10.3389/fmicb.2021.707330
3. Pro zatverdzhennia Zminy do Kryteriiv, za yakymy vyznachaiutsia vypadky infektsiinykh ta parazytarnykh zakhvoriuvan, yaki pidliahaiut reiestratsii : Nakaz Ministerstva okhorony zdorovia Ukrainy [On the approval of the Amendment to the Criteria for determining cases of infectious and parasitic diseases subject to registration : Order of the Ministry of Health of Ukraine]. ¹ 1447, 2021 Jul 15. Ukrainian. https://zakon.rada.gov.ua/laws/show/z1214-21#Text
4. WHO. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. Geneva: World Health Organization; 2017. 7 p.
5. Ma Y, Wang C, Li Y, Li J, Wan Q, Chen J, Tay FR, Niu L. Considerations and caveats in combating ESKAPE pathogens against nosocomial infections. Advanced Science. 2019 Dec 5;7(1):1901872. https://doi.org/10.1002/advs.201901872
6. Christenson EC, Cronk R, Atkinson H, Bhatt A, Berdiel E, Cawley M, Cho G, Coleman CK et al. Evidence map and systematic review of disinfection efficacy on environmental surfaces in healthcare facilities. International Journal of Environmental Research and Public Health. 2021 Oct 22;18(21):11100. https://doi.org/10.3390/ijerph182111100
7. Toufen Jr C, Franca S, Okamoto V, Salge J, Carvalho C. Infection as an independent risk factor for mortality in the surgical intensive care unit. Clinics. 2013 Aug 30;68(8):1103-8. https://doi.org/10.6061/clinics/2013(08)07
8. Sebre S, Abegaz WE, Seman A, Awoke T, Desalegn Z, Mihret W, Mihret A, Abebe T. Bacterial profiles and antimicrobial susceptibility pattern of isolates from inanimate hospital environments at tikur anbessa specialized teaching hospital, addis ababa, ethiopia. Infection and Drug Resistance. 2020 Dec; 13:4439-48. https://doi.org/10.2147/idr.s286293
9. Chng KR, Li C, Bertrand D, Ng AH, Kwah JS, Low HM, Tong C, Natrajan M, Zhang MH, et al. Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment. Nature Medicine. 2020 Jun;26(6):941-51. https://doi.org/10.1038/s41591-020-0894-4
10. Salmanov A, Shchehlov D, Artomenko V. Strymuvannia antymikrobnoi aktyvnosti na pidkhodakh «Yedyne zdorovia» [Controlling antimicrobial activity using «One Health» approaches]. Kyiv: AhrarMediaHrup; 2022. 380 p. Ukrainian.
11. Pro zatverdzhennia Poriadku provedennia posylenoho epidemiolohichnoho nahliadu za protymikrobnoiu rezystentnistiu mikroorhanizmiv, shcho sprychyniaiut hniino-zapalni infektsii ran u poranenykh vnaslidok boiovykh dii [On the approval of the attachment of an enhanced epidemiological survey for the antimicrobial systemicity of microchanisms contributing to fire-burn infection in those injured as a result of hostilities: Order of the Ministry of Health of Ukraine], ¹ 403, 2023 Feb 27. Ukrainian. https://zakon.rada.gov.ua/laws/show/z0489-23#Text
12. Pro zatverdzhennia Poriadku zdiisnennia dozornoho epidemiolohichnoho nahliadu za protymikrobnoiu rezystentnistiu [On the approval of the procedure for carrying out sentinel epidemiological surveillance of the antimicrobial system : Order of the Ministry of Health of Ukraine], ¹ 1766, 2021 Aug 19. Ukrainian. https://zakon.rada.gov.ua/laws/show/z1316-21#Text
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