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Ļ 4 (101), 2021


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 1 (77)   -   2016   -   Pages: 4-8
About possible mechanisms of benzo(a)pyrene influence of the atmospheric contamination on the formation of thyroid cancer morbidity in the population
Balenko N.V.1, Tsymbaliuk S.N.1, Chernichenko I.O.1, Ostash O.M.1
1 State Institution "O.M. Marz≥eiev Institute for Public Health of the NAMSU"

”ń : 614.71:547.681:612.44:616-006

We elucidated the possible mechanisms of benzo(a)pyrene influence on the formation of thyroid cancer morbidity in the population.

Materials and Methods: Analysis of our own and literary data. We applied the method of theoretical analysis of the scientific and methodological literature (compilation, synthesis and abstraction) on the biological effects of this compound and the regularities of their manifestation.

Results. The results of the performed analysis allowed to suppose that under chronic enter of benzo(a)pyrene into the organism it may produce different effects leading to a disturbance of synthesis and a decrease of thyroid hormonesí levels, that cause the activation of the thyrocitesí proliferation, development of hyperplasia, goiter. Besides, carcinogen induces also genetic and epigenetics changes in the invariable and proliferating cells at the thyroid nodal diseases, and mutations are their consequences. Stable induction of mentioned changes and simultaneous availability of the disturbances of immune system, caused by carcinogen and may promote a contribution of carcinogen together with the effect of other factors into increase of the risk and acceleration of the development of thyroid cancer in the population.

thyroid cancer, benzo(a)pyrene, mechanism of influence.
1. Hulchii M.V., Tsymbaliuk S.M., Chernychenko I.O., Korzun V.N., Bahlii Ye.A. Do pytannia stosovno vplyvu kantserohenonebezpechnykh faktoriv dovkillia na rozvytok raku shchytopodibnoi zalozy [About the Issue on the Environmental Carcinogenic Risk Factorsí Effect on the Development of Thyroid Cancer]. In : Aktualni pytannia hihiieny ta ekolohichnoi bezpeky Ukrainy [Topical Problems of Hygiene and Ecological Safety of Ukraine ]. Kyiv ; 2012; 12 : 217-218 (in Ukrainian).
2. Chernychenko I.O., Lytvychenko O.M., Tsymbaliuk S.M., Hulchii Ő.V., Fedorenko Z.P. Khimichni kantseroheny i rak shchytopodibnoi zalozy [Chemical Carcinogens and Thyroid Cancer]. In : Aktualni pytannia hihiieny ta ekolohichnoi bezpeky Ukrainy [Topical Problems of Hygiene and Ecological Safety of Ukraine]. Kyiv ; 2015 ; 15 : 175-176 (in Ukrainian).
3. State of the Science of Endocrine Disrupting —hemicals Ė 2012. - Available at : http://www.who. int/ceh/publications/endocrine/en/
4. Baskov A.Ya., Tulenkov N.V. Metodologiia nauchnogo analiza [Methodology of the Scientific Analysis]. Kiev : MAUP ; 2004 : 215 p. (in Russian).
5. Rom W.N. (ed.) Environmental and Occupational Medicine. New-York ; 1998 : 1437 p.
6. Some Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures. Lyon : IARC, 2010.
7. Opinion of the Scientific Comittee on Food on Risks to Human Health of Polycyclic Aromatic Hydrocarbons in Food. Brussels ; 2002 : 84p.
8. Burchiel S.W. and Luster M.I. Clin. Immunol. 2001 ; 98 (1) : 2-10. DOI : https://doi.org/10.1006/clim.2000.4934
9. Chernychenko I.O., Balenko N.V., Ostash O.M., Vynarska O.I., Hryhorenko L.Ye., Lukianchuk S.V. Dovkillia ta zdorovia. 2012 ; 1 : 6-13 (in Ukrainian).
10. 10. Chernychenko I.O., Balenko N.V., Ostash O.M., Vynarska O.I., Hryhorenko L.Ye., Lukianchuk S.V. Dovkillia ta zdorovia. 2012 ; 2 : 3-8 (in Ukrainian).
11. Vynarska O.I., Ostash O.M., Chubuk T.A., Grygorenko L.Ye., Lukianchuk S.V. Doslidzhennia pokaznykiv imunolohichnoho statusu myshei cherez 6 misiatsiv peroralnoho vvedennia ben(a)pirenu ta fenolu [Study of the Indices of the Immunological Status of Mice within 6 Months of Benzopyrene and Phenol Peroral Administrations]. In : Hihiiena naselenykh mists [Hygiene of Settlements]. Kyiv ; 2011 ; 57 : 161-168 (in Ukrainian).
12. Leux C., Guenel P. Rev Epidemiol Sante Publique. 2010 ; 58(5) : 359-367. DOI : https://doi.org/10.1016/j.respe.2010.05.005
13. Burek C.L., Talor M.V. J. Autoimmun. 2009 ; 33 (3-4) : 183-189. DOI : https://doi.org/10.1016/j.jaut.2009.09.001
14. Bezrukov O.F. Antropogennoe zagriaznenie kak faktor, sposobstvuiushchii vozniknoveniiu patologii shchitovidnoi zhelezy [Anthropogenic Contamination as a Factor Promoting the Beginning of Thyroid Pathology]. In : Problemy, dostizheniia i perspektivy razvitiia mediko-biologicheskikh nauk i prakticheskogo zdravookhraneniia [Problems, Achievements, and Prospects of the Development of Medico-Biological Sciences and Practical Health Protection]. Simferopol ; 2007 ; 143 : 29-36 (in Russian).
15. Zhu P., Bian Z., Xia Y., Han Y., Qiao S., Zhao R., Jin N., Wang S., Peng Y., Wang X. Chemosphere. 2009 ; 77(7) : 883-888. DOI : https://doi.org/10.1016/j.chemosphere.2009.08.054
16. Luzhetskii K.P., Ustinova O.Yu., Maklakova O.A., Palagina L.N. Analiz riska zdoroviu. 2014 ; 2 : 97-103 (in Russian).
17. Wong E.Y., Ray R., Gao D.L., Wernli K.J., Li W., Fitzgibbons E.D., Feng Z., Thomas D.B., Checkoway H. Int. Arch. Occup. Environ. Health. 2006 ; 79 : 251-258. DOI : https://doi.org/10.1007/s00420-005-0036-9
18. Song M., Kim Y.J., Park Y.K., Ryu J.C. J. Environ. Monit. 2012 ; 14 (8) 2121: 2126. DOI : https://doi.org/10.1039/c2em30106g
19. Montano M., Weiss G., Hoffman L., Gutleb A.Ch., Murk A.T.J. Environ. Sci. Technol. 2013; 47(15) ; 8876-8886.
20. Csaba G., Increfi-Gonda A. Hum. Exp. Toxicol. 1998 ; 17 (2): 88-92. DOI : https://doi.org/10.1177/096032719801700203
21. Zhang X., Shuk-Mei Ho J. Mol. Endocrinol. 2011; 46 (1) : R11-32. https://doi.org/10.1677/JME-10-0053
22. Murphy K.A., Quadro L., White L.A. Vitam Horm. 2007 ; 75 : 33-67. DOI : https://doi.org/10.1016/S0083-6729(06)75002-6
23. Bobyrova L.Ye., Muravlova O.V., Horodynska O.Yu. Problemy endokrynnoi patolohii. 2014 ; 1 : 15-23 (in Ukrainian).
24. Goncharova O.A. Endokrinolog≥ia. 2014 ; 19 (2) : 149-155 (in Russian).
25. Falfushynska H.I., Hnatyshyna L.L., Shidlovskyi V.O., Stoliar O.B. Endokrynolohiia. 2014 ; 19 (2) : 93-98 (in Ukrainian).
26. Pogribny I.P. Exp. Oncol. 2010 ; 32 (3) : 132-136.
27. Baccarelli A., Bolati V. Curr. Opin. Pediatr. 2009 ; 21(2) : 243-251. DOI : https://doi.org/10.1097/MOP.0b013e32832925cc
28. Xing M., Usadel H., Cohen Y., Tokumaru Y., Guo Z., Westra W.B., Tong B.C., Tallini G., Udelsman R., Califano J.A., Ladenson P.W., Sidransky D. Cancer Research. 2003 ; 63 (9) : 2316-2321.
29. Liu W.B., Liu G.Y., Ao L., Zhou Z.Y., Zhou Y.H., Cui Z.H., Yang H., Cao J. Toxicol. Lett. 2009 ; 189 (1) : 5-13. DOI : https://doi.org/10.1016/j.toxlet.2009.04.022
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