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Ļ 4 (101), 2021


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 1 (77)   -   2016   -   Pages: 4-8
About possible mechanisms of benzo(a)pyrene influence of the atmospheric contamination on the formation of thyroid cancer morbidity in the population
Balenko N.V.1, Tsymbaliuk S.N.1, Chernichenko I.O.1, Ostash O.M.1
1 State Institution "O.M. Marz≥eiev Institute for Public Health of the NAMSU"

”ń : 614.71:547.681:612.44:616-006

ABSTRACT:
We elucidated the possible mechanisms of benzo(a)pyrene influence on the formation of thyroid cancer morbidity in the population.

Materials and Methods: Analysis of our own and literary data. We applied the method of theoretical analysis of the scientific and methodological literature (compilation, synthesis and abstraction) on the biological effects of this compound and the regularities of their manifestation.

Results. The results of the performed analysis allowed to suppose that under chronic enter of benzo(a)pyrene into the organism it may produce different effects leading to a disturbance of synthesis and a decrease of thyroid hormonesí levels, that cause the activation of the thyrocitesí proliferation, development of hyperplasia, goiter. Besides, carcinogen induces also genetic and epigenetics changes in the invariable and proliferating cells at the thyroid nodal diseases, and mutations are their consequences. Stable induction of mentioned changes and simultaneous availability of the disturbances of immune system, caused by carcinogen and may promote a contribution of carcinogen together with the effect of other factors into increase of the risk and acceleration of the development of thyroid cancer in the population.


KEYWORDS:
thyroid cancer, benzo(a)pyrene, mechanism of influence.
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