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JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 2 (103)   -   June, 2022   -   Pages: 42-48
On the issue of revising the regulatory framework for chemical carcinogens in the air according to the risk criterion
Chernychenko I.O.1, Lytvychenko O.M.1, Babii V.F.1, Harkavyi S.I.2, Balenko N.V.1, Kondratenko O.Ye.1, Hlavachek D.O.1
1 State Institution "O.M. Marz³eiev Institute for Public Health of the NAMSU", Kyiv
2 Bohomolets National Medical University, Kyiv

ÓÄÊ: 614.7 : 615.9 : 616-006

ABSTRACT:
The aim of the work was to analyze the risk of carcinogenic substances in populated areas and industrial zone, included in domestic regulatory frameworks, in accordance with international qualification standards, and to determine the safety level of existing hygienic standards for humans by specific oncogenic hazard criteria.

Materials and methods. Bibliosemantic, bibliographic and hygienic research methods was used in the work. The results were obtained on the basis of collection and analysis of data on chemical carcinogenic compounds that are dangerous to humans, according to international directives, domestic and foreign regulatory frameworks. Carcinogenicity indicators was identified to assess the hazards of certain substances and hygienic regulatory levels.

Research results and their discussion. The analysis of national and international databases on carcinogenic compounds, assessment of their physicochemical properties, dose-effect response and health effects was carried out. It was shown that today the most recognized and widespread base of the International Agency for Research on Cancer, in which based on a critical analysis of experimental and epidemiological data of more than 1000 chemical factors, their classification was carried out according to the degree of evidence of carcinogenic hazard to humans, the hygienic expression of which is carcinogenic risk.
The analysis of domestic databases of hygienic standards for the permissible content of chemicals showed that only for 131 carcinogenic substances the MPC in the air is justified, however, according to the criterion of carcinogenic risk, most of them do not meet the requirements of the EU and world practices, which indicates the need for their revision.
It is emphasized that one of the available and adequate methods of this task is the principle laid down in determining the relationship "concentration - risk (acceptable risk)".

Conclusions. It was shown that according to the criterion of carcinogenic risk, the hygienic standards of most carcinogenic substances included in domestic regulatory air bases do not meet the requirements of the EU and international practices, which indicates the need to revise them based on acceptable risk.

KEYWORDS:
chemical carcinogens, air environment, regulatory frameworks, hygienic standards, carcinogenic risk
REFERENCES:
1. Naghavi M. The Global Burden of Cancer 2013. JAMA Oncology. 2015 ; 1 (4) : 505 - 527. DOI : https://doi.org/10.1001/jamaoncol.2015.0735
2. Ferlay J., Soerjomateram I., Ervik M. et al. Cancer Incidence and Mortality Worldwide. International Journal of Cancer. 2015 ; 136 (5) : 359 - 386. DOI : https://doi.org/10.1002/ijc.29210
3. WHO Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All. Geneva : WHO; 2020 : 160 p. URL: https://apps.who.int/iris/handle/10665/330745
4. Bray F., Ferlay J., Soerjomataram I. et al. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2019 ; 10(17) : 4054 - 4062. DOI : https://doi.org/10.3322/caac.21492
5. Pidbirka shchorichnykh biuleteniv ta inshykh publikatsii Natsionalnoho kantser-reiestru Ukrainy. [Collection of Annual Bulletins and Other Publications of the National Cancer Registry of Ukraine]. URL: http://www.ncru.inf.ua/publications/index.htm
6. World Cancer Report (ed. by B.W. Stewart, C.P. Wild). Lyon : JARÑ Press; 2020 : 594 p.
7. JARC Monographs on the Evaluation of the Carcinogenic Risks to Humans. URL : http://monographs.iarc.fr/
8. Basic Documents: Forty-Ninth Edition (Including Amendments Adopted up to 31 May 2019). Geneva : WHO ; 2020. 244 p. URL: https://apps.who.int/gb/bd/pdf_files/BD_49th-ru.pdf
9. Pro zatverdzhennia hihiienichnoho normatyvu «Perelik rechovyn, produktiv, vyrobnychykh protsesiv, pobutovykh ta pryrodnykh faktoriv, kantserohennykh dlia liudyny». Derzhavnyi hihiienichnyi normatyv. Nakaz MOZ ¹ 7 vid 13.01.2006. [About the Statement of the Hygienic Standard "The List of Substances, Products, Production Processes, Household and Natural Factors Carcinogenic to the Person". State Hygienic Standard. Order of the Ministry of Health ¹ 7 of 13.01.2006]. URL: https://zakon.rada.gov.ua/laws/show/z0100-06#Text
10. Hihiienichni rehlamenty. Hranychno dopustymi kontsentratsii khimichnykh i biolohichnykh rechovyn v atmosfernomu povitri naselenykh mists. Nakaz MOZ ¹ 52 vid 14.01.2020. [Hygienic regulations. Maximum permissible concentrations of chemical and biological substances in the atmospheric air of populated areas. Order of the Ministry of Health No. 52 of 01.14.2020]. URL: http://online.budstandart.com/ua/catalog/doc-page.html?id_doc=81980
11. Pro zatverdzhennia hihiienichnykh rehlamentiv dopustymoho vmistu khimichnykh i biolohichnykh rechovyn u povitri robochoi zony. Nakaz Ministerstva okhorony zdorovia Ukrainy vid 14 lypnia 2020 r. ¹ 1596. [About the Statement of Hygienic Regulations of Admissible Maintenance of Chemical and Biological Substances in Air of a Working Zone. Order of the Ministry of Health of Ukraine of July 14, 2020 ¹ 1596]. URL: https://zakon.rada.gov.ua/laws/show/z0741-20#Text
12. Otsinka ryzyku dlia zdorovia naselennia vid zabrudnennia atmosfernoho povitria. Metodychni rekomendatsii. MR 2.2.12 - 142 -2007. [Assessment of Public Health Risk from Atmospheric Air Pollution. Guidelines 2.2.12 - 142 -2007]. Kyiv; 2007 : 39 p. (in Ukrainian).
13. Valavonidis A. Environmental Carcinogenic Substances. Exposure and Risk Assessment for Carcinogenic Potential. Classifications and Regulations by International and National Institutions. 2017. URL: https://www.researchgate.net/publication/317823912_Environmental_Carcinogenic_Substances_Exposure_and_Risk_Assessment_for_Carcinogenic_Potential_Classification_and_Regulations_by_International_and_National_Institutions
14. IRIS Databases for Risk Assessment. URL: https://iris.epa.gov/AtoZ/?list_type=erd
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