Home Page   -   ditorial Board   -   Instructions to autors   -   Archive   -   Contact   -   Journal's Indexing UA   EN

Last issue

2 (95), 2020


Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.


ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 4 (93)   -   2019   -   Pages: 38-43
Comparative analysis of the state of pro- and antioxidant systems in children under the influence of stress factors of radiation and psychogenic origin
Stepanova Ye.I.1, Kolpakov I.Ye.1, Poznysh V.A.1, Vdovenko V.Yu.1, Zygalo V.M.1, Alekhina S.M.1
1 SI National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Kyiv,

: 616.211-008.4-053.2:612.176:504.054(1-074)

Objective: We evaluated the processes of lipid peroxidation and antioxidant protection in children under the influence of stress factors of radiation and psychogenic origin.

Materials and methods: The children of school age residents of radioactive contaminated territories (RCT) and children-forced migrants from the armed conflict zone exposed to stress factors, were examined. The final products of lipid peroxidation (LPO) reacting with thiobarbituric acid (malondialdehyde MDA), enzymes-antioxidants catalase, superoxide dismutase, glutathione peroxidase, glutathione transferase were studied by us to determine the signs of oxidative stress.

Results and conclusions: In children-residents of RCT and children-displaced from the zone of armed conflict, the imbalance in the LPO system was revealed, an antioxidant protection is morepronounced among children-residents of RCT. An increase in the serum content of end-products of lipid peroxidation reacting with thiobarbituric acid was observed in children-residents of RCT compared with the control; changes in the activity of antioxidant enzymes such as a decrease in the activity of superoxide dismutase, an increase in catalase activity, glutathione peroxidase, glutathione transferase were observed. In children-migrants from the zone of armed conflict, changes in indicators of the intensity of LPO processes and the activity of enzymes in the antioxidant defense system were unidirectional, but were less pronounced.

children, radioactive contaminated territories, zone of armed conflict, lipid peroxidation, antioxidant protection.
1. Stepanova Ye.., Bazyka D.., Poznysh V.., Yaroshenko Zh.S., Studenikina .., Vdovenko V.Yu., Leonovych .S. and Hrytsenko .. Medyko-psykholohichni problemy ditei, peremishchenykh z zony ATO [Medico-Psychological Problems of the Children Displaced from the ATO Zone.] In : Medychne zabezpechennia antyterorystychnoi opertsii. Naukovo-orhanizatsiini ta medyko-sotsialni aspekty: zb. nauk. prats.[Medical Support for Anti-Terrorist Operation. Scientific-and-Organizational and Medico-Social Aspects : Coll. Sci.Works.]. Kyiv ; 2016 : 193199 (in Ukrainian).
2. Poznysh V.. Zhurnal NAMN Ukrainy. 2018 ; Special Iss. : 8384 (in Ukrainian).
3. Horot .V. and Tkachenko . . Problems of Radiation Medicine and Radiobiology . 2017 ; 22 : 184201 (in Ukrainian). URL : http://radiationproblems.org.ua/22_2017/NCRM_2017_13.pdf
4. Pobedionna H.P. Likarska sprava (Vrachebnoe delo). 2005 ; 5/6 : 3640 (in Ukrainian).
5. Tregubova I.., Kosolapov V.. and Spasov .. Uspekhi fiziologicheskikh nauk. 2012 ; 43 (1) : 75-94 (in Russian).
6. Chanchaeva E.., Aizman R.I. and Gerasev .D. Ekologicheskaya fiziologiya. Ekologiya cheloveka. 2013 ; 7 : 50-57 (in Russian).
7. Research Center for Radiation Medicine. Metody otsinky vilnoradykalnoho okyslennia ta stanu antyoksydantnoi systemy orhanizmu u klinichnii praktytsi: metodychni rekomendatsii [Methods of the Evaluation of Free Radical Oxidation and State of Antioxidant System of the Organism in Clinical Practice : Methodical Recommendations ]. Kyiv ; 2007 : 23 p. (in Ukrainian).
8. Karpishchenko A.M. (ed.) [Medical Laboratory Technologies: Reference Book]. Sankt-Peterburg : Intermedika ; 1992 ; 2 : 2324 (in Russian).
9. Farkhutdinova L.. Vestnik Akademii Nauk RB. 2015 ; 20 (1) : 42-49 (in Russian).
10. Lutskiy .., Zemskov .., Razuvaeva V.V., Lushnikova Yu.P. and Karpova .Yu. Zhurnal nevrologii I psikhiatrii im. S.S. Korsakova. 2016 ; 8 (2) ; 24-29 (in Russian). DOI : https://doi.org/10.17116/jnevro20161168224-29
11. Kocherha Z.. and Ersteniuk H.. Odeskyi medychnyi zhurnal. 2014 ; 146 (6) : 51-54 (in Ukrainian).
Designed by: IPH NAMSU Environment & Health, 2006-2020. All rights reserved.
Use of text and graphic materials of the site is allowed only upon written permission of the editoral board.