Hyperhomocysteinemia in children and forest fires in the Chоrnobyl exclusion zone
DOI:
https://doi.org/10.32402/dovkil2020.04.021Keywords:
folate metabolism, homocysteine, adolescents, forest fires, Chоrnobyl exclusion zoneAbstract
Objective: We determined a role of folate metabolism genotypes in the occurrence of hyperhomocysteinemia in children after a forest fire in the Chоrnobyl exclusion zone (ChEZ). Material and methods: In the study, we applied immunochemical, Real-time PCR, mathematical and statistical methods. Results: A survey of 84 adolescents from the Poliske district, Kiev region revealed changes in their metabolic processes in the form of increased homocysteine production in connection with a forest fire in the ChEZ which was recorded during April 26-29, 2015. A comparative analysis of the specific gravity of the folate cycle genotypes in the subgroups of the children with hyperhomocysteinemia before and after a forest fire showed that an endogenous factor in the form of a genetic apparatus, controling synthesis of folate cycle enzymes, was not involved in this phenomenon. Сonclusions: Forest and peat fires in the Chernobyl exclusion zone are one of the main causes for the elevation in blood homocysteine levels in children from the adjacent districts, regardless of the state of folate metabolism genetic system. Monitoring of the blood homocysteine levels in children and adults living under conditions of the exposure to wood combustion gases, containing radioactive elements, is a key component of the programmer for the prevention of cancer and cardiovascular diseases.Downloads
References
1. Bandazhevski Yu.I., Dubovaya N.F. Folate metabolism gene polymorphisms and homocysteinemia in children from families continuously living in an area affected by the Chоrnobyl nuclear power plant accident. Collection of Scientific and Practical Articles «Chоrnobyl: Ecology and Health»: Under general editorship of Prof. Yu.І. Bandazhevsky. Іssue 3. Ivankov : PI Coordination andAnalytical Center «Ecology and Health». Dnipropetrovsk : Serednyak Т.К., 2015. Р. 16-25.
2. Lentz S.R., Haynes W.G. Homocysteine: is it a clinically important cardiovascular risk factor? Clin. J. Med. 2004. Vol. 71. P. 729-734.
3. Bandazhevsky Yu.I., Dubova N.F. Assessment of folate metabolism functioning in terms of prevention of breast cancer in the population living in areas affected by the Chernobyl nuclear power plant accident. Збірка наукових праць співробітників НМАРО ім. П.Л. Шупика.2017. Вип. 27. С. 215-225.
4. Bandazhevskyi Yu.I., Dubova N.F. MTHFR:677ТТ genotype and state of hyperhomocysteinemia in the children of regions suffered as a result of the accident at the Сhоrnobyl nuclear power plant. Dovkillia ta zdorovia (Environment & Health). 2018. № 2 (86). P. 10-15. DOI : https://doi.org/10.32402/dovkil2018.02.010
5. Колпакова А.Ф., Шарипов Р Н., Волкова О.А. Влияние загрязнения атмосферного воздуха взвешенными веществами на сердечно-сосудистую систему. Сибирский медицинский журнал. 2015. Т. 30. № 3. С. 7-12.
6. Pope C.A., Turner M.C., Burnett R. et al. Relationships between fine particulate air pollution, cardiometabolic disorders and cardiovascular mortality. Circ. Res. 2015. Vol. 116, № 1. P.108-115. DOI : https://doi.org/10.1161/CIRCRESAHA.116.305060
7. Park S.K., O’Neill M.S., Vokonas P.S. et al. Traffic related particles are associated with elevated homocysteine. The VA Normative Aging Study. Am. J. Respir. Crit. Care Med. 2008. Vol. 178. P. 283-289. DOI : https://doi.org/10.1164/rccm.200708-1286OC
8. Кашпаров В.А., Миронюк В.В., Журба М.А. и др. Радиологические последствия пожара в Чернобыльской зоне отчуждения в апреле 2015 года. Радиационная биология. Радиоэкология. 2017. Т. 57. № 5. С. 512-527. DOI : https://doi.org/10.7868/S0869803117050071
9. Загальнодозиметрична паспортизація та результати ЛВЛ-моніторингу у населених пунктах України, які зазнали радіоактивного забруднення після Чорнобильської катастрофи. Дані за 2011 рік. Збірка 14. К.: МОЗ України, 2012. 99с.
10. Богорад В.И., Литвинская Т.В., Шевченко И.А., Дыбач А.М., Слепченко А.Ю. Радиационные последствия пожара в зоне отчуждения Чернобыльской АЭС. Ядерна та радіаційна безпека. 2016. Т. 69. № 1. С. 64-68. DOI : https://doi.org/10.32918/nrs.2016.1(69).10
11. Ren C., Park S., Vokonas P., Sparrow D. et al. Air Pollution and Homocysteine: More Evidence that Oxidative Stress-related Genes Modify Effects of Particulate Air Pollution. Epidemiology. 2010. Vol. 21. № 2. P. 198-206.
12. Bandazhevski Yu.I., Dubovaya N.F., Bandazhevskaya G.S. et al. Assessment of the cardiovascular system in children from Polesie and Ivankov districts. Collection of Scientific and Practical Articles «Chernobyl: Ecology and Health»: Under general editorship of Prof. Yu.І. Bandazhevsky. Іssue 2. Ivankіv : PI Coordination and Analytical Center «Ecology and Health»; Dnipropetrovsk : Serednyak Т.К., 2015. P. 22-35.
13. Шейбак В.М., Лелевич В.В., Бандажевский Ю.И. Свободные аминокислоты плазмы крови и тканей животных после инкорпорации радионуклидов цезия и стронция. Клинико-экспериментальные аспекты влияния инкорпорированных радионуклидов на организм. Под ред. Ю.И. Бандажевского, В.В. Лелевича. Гомель, 1995. С. 101-127.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 Environment & Health
This work is licensed under a Creative Commons Attribution 4.0 International License.
