Genetic control of homocysteine metabolism in children living near the chоrnobyl exclusion zone

Ю.І. Бандажевський; Н.Ф. Дубова

doi:10.32402/dovkil2022.02.010

Authors

Yu.I. Bandazhevskyi Ecology and Health Coordination and Analytical Centre, Ivankiv Author
N.F. Dubova Shupyk National Healthcare University of Ukraine, Kyiv Author

DOI:

https://doi.org/10.32402/dovkil2022.02.010

Keywords:

homocysteine, adolescent children, radionuclides, Chornobyl еxclusion zone

Abstract

The aim of study: to determine the involvement of folate cycle genes in the occurrence of hyperhomocysteinemia in children from Ivankivskyi district of Kyiv region of Ukraine 35 years after the accident at the Chornobyl nuclear power plant. Research methods. Immunochemical, mathematical and statistical. Results. Homocysteine levels were determined in 217 children aged 12-17 from Ivankivskyi district of Kyiv region, as well as genetic polymorphisms of the folate cycle. An excess of homocysteine in the blood over 10 µmol/l (a state of hyperhomocysteinemia) was detected in 65.44 % (142 out of 217) of those examined, among boys – 69.79 % (67 out of 96), among girls – 61.98 % (75 out of 121). The largest proportion of hyperhomocysteinemia cases was registered in the subgroup of children with the basic polymorphism MTHFR: 677TT – 94.44 % of cases. In most cases, hyperhomocysteinemia in children was associated with an environmental factor, including radioactive elements and their decay products. The system for the prevention of hyperhomocysteinemia and its consequences in children living in areas affected by the accident at the Chornobyl nuclear power plant should include regular monitoring of the content of radionuclides in the body of children and locally produced food, the content of homocysteine in the blood, and assessment of the state of folate cycle genes.

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References

1. Бандажевский Ю.И., Дубовая Н.Ф. Гипергомоцистеинемия и В12-фолиевый дефицит у детей, проживающих на территории, загрязненной радионуклидами в результате аварии на Чернобыльской атомной электростанции. Педиатрия. Восточная Европа. 2017. Том 5. № 1. С. 25-32.

2. Mc Cully KS. Homocysteine and the pathogenesis of atherosclerosis. Expert Review of Clinical Pharmacology. 2015. Vol. 8(2). 211-9. DOI: https://doi.org/10.1586/17512433.2015.1010516

3. Полушин А.Ю., Одинак М.М., Янишевский С.Н и др. Гипергомоцистеинемия – предиктор тяжести инсульта на фоне обширности повреждения мозгового вещества. Вестник Российской военно-медицинской академии. 2013. №4. С. 89 - 94.

4. Keshteli A., Baracos V., Madsen K. Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases : A review. World J Gastroenterol. 2015. Vol. 21(4). C. 1081 -1090. doi: 10.3748/wjg.v21.i4.1081 https://doi.org/10.3748/wjg.v21.i4.1081

5. Tronko M., Bogdanova T., Saenko V. et al. Thyroid cancer in Ukraine after Chernobyl. Dosimetry, epidemiology, pathology, molecular biology. Nagasaki : Nagasaki Association for Hibakushas ґMedical Care (NASHIM), 2014. 175 p.

6. Bandazhevsky Yu.I. Improvement of quality of life in the population of Ivankov and Polesie districts by preventing conditions associated with the impact of environmental factors. Chernobyl: ecology and health : Scientific and practical collection. Ivankov PI Coordination and Analytical Center «Ecology and health». Dnipro : Serednyak Т.К., 2017. № 6. P.12-15.

7. Bandazhevsky Yu.I., Dubovaya N.F. Forest fires in the Chernobyl exclusion zone and children’s health. Ivankov PI Coordination and Analytical Center «Ecology and health». Kyiv : Aliant LLC, 2021. 44 p.

8. Bandazhevsky Yu.I., Dubovaya N.F. Chernobyl catastrophe and childrens health. 35 years of world tragedy. Ivankov PI Coordination and Analytical Center «Ecology and health». Kyiv : Alyant LLC, 2022. 158 p.

9. Бандажевский Ю.И., Дубовая Н.Ф., Бандажевская Г.С. и др. Чернобыль 25 лет: инкорпорированные радионуклиды Cs-137 и здоровье люде. Под ред. проф. Ю. И. Бандажевского ; Координационный аналитический центр «Экология и здоровье». К., 2011. 156 с.