Іntegrated system for the prevention of hyperprolactinemia in women with metabolic syndrome

Authors

  • O. Yu. Mykhailenko State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Kyiv Author

DOI:

https://doi.org/10.32402/dovkil2026.01.031

Keywords:

hyperprolactinemia, metabolic syndrome, prevention, prolactin, insulin resistance

Abstract

The aim. To substantiate and systematize an integrated model for the prevention of hyperprolactinemia in women with metabolic syndrome. Materials and methods. The study involved 203 women of reproductive age from 20 to 49 years, who were verified to have metabolic syndrome. All patients underwent laboratory and clinical examination with determination of prolactin, total cholesterol, glucose, Noma index, leptin. The hardware examination was performed using magnetic resonance tomography. The analysis of the study results was performed using IBM SPSS Statistics version 26 software. Results. A comprehensive prevention system is proposed, including lifestyle modification, psychoemotional stabilization, correction of metabolic disorders, pharmacological and educational interventions. Conclusions. An integrated approach allows you to influence all pathogenetic links in the formation of metabolic syndrome. The most effective is a combination of non-drug and pharmacological measures. Psycho-emotional correction is a necessary component of prevention.

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References

1. Zaidalkilani AT, Al ­Kuraishy HM, Al ­Gareeb AI, Alexiou A, Papadakis M, Al­Farga A, et al. The beneficial and detrimental effects of prolactin hormone on metabolic syndrome: Adoubleedge sword. J Cell Mol Med. 2024;28(23):e70067. doi: 10.1111/jcmm.70067

2. Macotela Y, Ruiz­Herrera X, Vázquez­Carrillo DI, Ramírez­Hernandez G, Martínez de la Escalera G, Clapp C. The beneficial metabolic actions of prolactin. Front Endocrinol (Lausanne). 2022;13:1001703. doi: 10.3389/fendo.2022.1001703

3. Macotela Y, Triebel J, Clapp C. Time for a New Perspective on Prolactin in Metabolism. Trends Endocrinol Metab. 2020;31(4):276–86. doi: 10.1016/j.tem.2020.01.004

4. Iancu ME, Albu AI, Albu DN. Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes-A Review of the Literature. Pharmaceuticals (Basel). 2023;16(1):122. doi: 10.3390/ph16010122

5. Hannan FM, Elajnaf T, Vandenberg LN, Kennedy SH, Thakker RV. Hormonal regulation of mammary gland development and lactation. Nat Rev Endocrinol. 2023;19(1):46–61. doi: 10.1038/s41574-022-00742-y

6. Gierach M, Bruska­Sikorska M, Rojek M, Junik R. Hyperprolactinemia and insulin resistance. Endokrynol Pol. 2022;73(6):959–67. doi: 10.5603/EP.a2022.0075

7. Pirchio R, Graziadio C, Colao A, Pivonello R, Auriemma RS. Metabolic effects of prolactin. Front Endocrinol (Lausanne). 2022;13:1015520. doi: 10.3389/fendo.2022.1015520

8. Glezer A, Santana MR, Bronstein MD, Donato J Jr, Jallad RS. The interplay between prolactin and cardiovascular disease. Front Endocrinol (Lausanne). 2023;13:1018090. doi: 10.3389/fendo.2022.1018090

9. Kirsch P, Kunadia J, Shah S, Agrawal N. Metabolic effects of prolactin and the role of dopamine agonists: A review. Front Endocrinol (Lausanne). 2022; 13:1002320. doi: 10.3389/fendo.2022.1002320

10. Yazici D, Sunbul M, Yasar M, Deyneli O, Yavuz D. Is there an increased cardiovascular risk in patients with prolactinoma? A challenging question. J Clin Ultrasound. 2021 Oct;49(8):870–7. doi: 10.1002/jcu.23030

11. Szukiewicz D. Current Insights in Prolactin Signaling and Ovulatory Function. Int J Mol Sci. 2024;25(4):1976. doi: 10.3390/ijms25041976

12. Guo H, Yang B, Kiryu S, Wang Q, Yu D, Sun Z, et al. Evaluation of the relations between reproduction-related pituitary and ovarian hormones and abdominal fat area-related variables determined with computed tomography in overweight or obese women who have undergone bariatric surgery: a cross-sectional study. Quant Imaging Med Surg. 2023;13(10):7065–76. doi: 10.21037/qims-22-1283

13. Mendoza RA, Grandner MA, Elali LS, Fernandez FX. Concerning the circadian rhythms of prolactin, its secretion timing, and regulation of the affiliative mind. Neurosci Biobehav Rev. 2025;179:106403. doi: 10.1016/j.neubiorev.2025.106403

14. Li Z, Zheng L, Wang J, Wang L, Qi Y, Amin B, et al. Dopamine in the regulation of glucose and lipid metabolism: a narrative review. Obesity. 2024;32(9):1632–45. doi: 10.1002/oby.24068

15. Barber TM, Kyrou I, Kaltsas G, Grossman AB, Randeva HS, Weickert MO. Mechanisms of Central Hypogonadism. Int J Mol Sci. 2021;22(15):8217. doi: 10.3390/ijms22158217

16. Auriemma RS, Pirchio R, Pivonello C, Garifa­los F, Colao A, Pivonello R. Approach to the Patient With Prolactinoma. J Clin Endocrinol Metab. 2023;108(9):2400–23. doi: 10.1210/clinem/dgad174

Published

2026-04-10

Issue

Section

SOCIAL DETERMINANTS OF PUBLIC HEALTH

How to Cite

Іntegrated system for the prevention of hyperprolactinemia in women with metabolic syndrome. (2026). Environment & Health, 118(1), 31-37. https://doi.org/10.32402/dovkil2026.01.031