ВИЗНАЧЕННЯ ЧУТЛИВОСТІ ДО АНТИБІОТИКІВ ЗБУДНИКІВ ІНФЕКЦІЙ, ВИДІЛЕННИХ ПРИ НАДАННІ МЕДИЧНОЇ ДОПОМОГИ, В УКРАЇНІ У 2023–2024 РОКАХ

О.В. Сурмашева; О.В. Молчанець; Т.Г. Глушкевич; А.М. Сбоєва; М.О. Росада; О.О. Полька

doi:10.32402/

Authors

O.V. Surmasheva State Institution “Marzieiev Institute for Public Health of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-7739-0295 Author
O.V. Molchanets State Institution “Marzieiev Institute for Public Health of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-9306-2777 Author
T.G. Glushkevych State Institution “Center for Public Health of the Ministry of Health of Ukraine”, Kyiv, Ukraine https://orcid.org/0009-0004-6417-8366 Author
A.M. Sboieva State Institution “Center for Public Health of the Ministry of Health of Ukraine”, Kyiv, Ukraine https://orcid.org/0009-0001-5920-5401 Author
M.O. Rosada State Institution “Center for Public Health of the Ministry of Health of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-2754-0715 Author
О.О. Polka State Institution “Marzieiev Institute for Public Health of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-7987-8355 Author

DOI:

https://doi.org/10.32402/

Keywords:

infections associated with the provision of medical care, conditionally-pathogenic bacteria, biological material, antibiotics.

Abstract

OBJECTIVE. The objective of work was to analyze the antibiotic sensitivity of pathogens of infections associated with the provision of medical care, which were isolated in Ukraine in 2023-2024.

MATERIALS AND METHODS. Identification of microorganisms and sensitiveness to antimicrobial preparations was conducted by means of microbiological analyzers of VITEK 2 Compact and MALDI Biotyper Sirius

RESULTS. Certain sensitiveness to the antibiotics of causative agents of the of infections associated with the provision of medical care, that is distinguished in Ukraine in 2023 and in 2024. Among investigational cultures, as well as in 2023 gramnegative microorganisms prevailed also – 87,7% , grampositive – 12,3%. Mostly distinguished strains of bacteria of K. pneumoniae, A.baumannii and P.aeruginos. Distinguished strains of K.рneumoniae, P.aeruginosa, A.baumannii appeared insensitive to the most studied antimicrobial preparations. The analysis of results of determination of sensitiveness of the distinguished strains to antimicrobial preparations showed their variability and necessity of determination of antibiotics sensitiveness for each distinguished etiologic.

CONCLUSIONS

1. Certain sensitiveness to the antibiotics of causative agents of the infections of infections associated with the provision of medical care, that is distinguished in Ukraine in 2023 and in 2024.

2. Gramnegative microorganisms prevailed among investigational cultures – 87,7%, grampositive is a 12,3%. All of strains of bacteria of K. рneumoniae, A.baumannii and P.aeruginosa were abstracted from all types of biological material.

3. Distinguished strains of K.рneumoniae, P.aeruginosa, A.baumannii appeared insensitive to the most studied antimicrobial preparations.

4. The results of determination of sensitiveness of the distinguished strains to antimicrobial preparations showed, that for treatment of diseases caused by conditionally – pathogenic causative agents, it was expedient to apply: for K. рneumoniae - kolistin; for E.coli – taigeciklin, kolistin; for P. aeruginosa – kolistin, for A.baumannii - kolistin; for S.aureus - taigeciklin, linezolid, vankomicin, teikoplanin, fuzidovacid; for E.faecium – tigeciklin, linezolid; for E.faecalis – аmpicilin, tigeciklin, linezolid, vankomicin, teikoplanin.

The got results of sensitiveness of the distinguished strains to antimicrobial preparations showed their variability and necessity of determination of antibiotic sensitivity for every distinguished etiologic causative agent.

Downloads

Download data is not yet available.

References

1. MacLean RC, San Millan A. The evolution of antibiotic resistance. Science. 2019;365(6458):1082–3.

doi: https://doi.org/10.1126/science.aax3879

2. Naghavi M, Vollset SE, Ikuta KS, Swetschinski LR, Gray AP, Wool EE, et al. Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050. Lancet. 2024;404(10459):1199–226.

doi: https://doi.org/10.1016/S0140-6736(24)01867-1

3. Murray CJL, Ikuta KS, Sharara F, Swetschinski L, Robles Aguilar G, Gray A, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629–55.

doi: https://doi.org/10.1016/S0140-6736(21)02724-0

4. World Health Organization. Global antibiotic resistance surveillance report 2025: WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS) [Internet]. Geneva: World Health Organization; 2025 [cited 2026 May 29]. Available from: https://www.who.int/publications/i/item/9789240116337

5. Rosada MO, Hlushkevych TG, Sboieva AM, Surmasheva OV, Molchanets OV. Mikrobiolohichnyi spektr zbudnykiv infektsii, poviazanykh z nadanniam medychnoi dopomohy, vydilenykh v Ukraini u 2022–2023 rokakh [Microbiological spectrum of causative agents of healthcare-associated infections isolated in Ukraine in 2022–2023]. Environment & Health. 2024;4(113):60–4. Ukrainian.

doi: https://doi.org/10.32402/dovkil2024.04.060

6. Surmasheva OV, Rosada MO, Hlushkevych TG, Sboieva AM. Bakterialni zbudnyky infektsii, poviazanykh z nadanniam medychnoi dopomohy, vydileni v Ukraini v 2022–2023 rokakh [Bacterial pathogens of infections associated with the provision of medical care, isolated in Ukraine in 2022–2023]. In: Zadorozhna VI, Serheieva TA, editors. Contemporary infectious diseases: etiology, epidemiology, diagnosis, treatment, prevention, biosafety: materials of the scientific and practical conference with international participation, Kyiv, 15 October 2024. Kyiv; 2024. p. 144–6. Ukrainian.

7. Latina NO, Surmasheva OV. Etiolohiia hniino-zapalnykh infektsii u postrazhdalykh osib cherez boiovi dii ta chutlyvist zbudnykiv do antymikrobnykh preparativ [Etiology of purulent-inflammatory infections in injuries caused by combat operations and sensitivity of pathogens to antimicrobial preparations]. Environment & Health. 2024;1(110):50–6. Ukrainian.

doi: https://doi.org/10.32402/dovkil2024.01.050