Hyperhomocysteinemia in children is an indicator of environmental problems associated with the chоrnobyl exclusion zone
DOI:
https://doi.org/10.32402/dovkil2022.03.014Keywords:
homocysteine, hyperhomocysteinemia, folate cycle genes, adolescent children, Chornobyl exclusion zoneAbstract
The aim of study: determination of the genetic factor’s involvement (MTHFR:C677T polymorphism), which affects the activity of the main enzyme of the folate cycle, methylenetetrahydrofolate reductase, and environmental exposure, including the radiation factor, in the occurrence of hyperhomocysteinemia in children which living near the Chornobyl Exclusion Zone (ChEZ). Research methods. Immunochemical, mathematical and statistical. Results. Within the framework of international projects, the levels of homocysteine (Hcy) and allelic variants of the genetic polymorphism MTHFR:C677T were determined in 624 children aged 13-17 years old from Ivankivskyi and Poliskyi districts of the Kyiv region. It has been established that an increase in the level of Hcy in the blood and an increase in the number of cases of hyperhomocysteinemia in the examined groups of children are associated with forest fires in the ChEZ in 2015 and 2020. Under conditions of pronounced exposure to radioactive agents and combustion products of forest trees, the proportion of cases of hyperhomocysteinemia in groups of children with and without the T allele of the MTHFR:677 polymorphism in the genome did not have statistical differences. An indicator of ecological trouble in the ChEZ and adjacent areas is an increase, above the physiological level, in the concentration of Hcy in the blood of adolescent children with the absence of the T allele of the MTHFR:677 polymorphism in the genome. Conclusion. In areas affected by the accident at the Chornobyl nuclear power plant, it is necessary to constantly conduct regular monitoring studies of the health of children, using tests for the content of Hcy in the blood and the state of the folate cycle genes.Downloads
References
1. Bandazhevsky Yu.I., Dubovaya N.F. Forest fires in the Chornobyl exclusion zone and children’s health. PI Coordination and Analytical Center «Ecology and health» (Ivankiv, Ukraine). Kyiv : Aliant LLC, 2021. 44 p.
2. Азаров С.І., Сидоренко В.Л., Руденко О.В. Вивчення процесу надходження радіонуклідів у повітря при пожежах у лісах зони відчуження ЧАЕС. Проблемы пожарной безопасности: сб. науч. тр. К., 2011. Вып. 30. С.16-23.
3. Bandazhevsky Yu.I., Dubovaya N.F. Chornobyl catastrophe and childrens health. 35 years of world tragedy. PI Coordination and Analytical Center «Ecology and health» (Ivankiv, Ukraine). Kyiv : Aliant LLC, 2022. 158 p.
4. Bandazhevsky Yu.I. Chronic Cs-137 incorporation in children's organs. Swiss Medical Weekly. 2003. Vol. 133. P. 488-490.
5. Бандажевский Ю.И., Дубовая Н.Ф., Бандажевская Г.С. и др. Чернобыль 25 лет: инкорпорированные радионуклиды Cs-137 и здоровье людей. Под ред. проф. Ю.И. Бандажевского. Координационный аналитический центр «Экология и здоровье». К., 2011. 156 с.
6. Ganguly P., Alam S. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015. Vol. 14 (6). P. 2 - 10. DOI : https://doi.org/10.1186/1475-2891-14-6
7. Antoniades C., Antonopoulos A., Tousoulis D., Marinou K., Stefanadis C. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. European Heart J. 2009. Vol. 30(1). P. 6 - 15. DOI : https://doi.org/10.1093/eurheartj/ehn515
8. Varshney K.K., Gupta J.K., Mujwar S. Homocysteine induced neurological dysfunctions: A link to neurodegenerative disorders. Int J Med Res Health Sci. 2019. Vol. 8(4). P. 135 - 146.
9. Keshteli A., Baracos V., Madsen K. Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases : A review. World J Gastroenterol. 2015. Vol. 21(4). P. 1081 - 1090. DOI : https://doi.org/10.3748/wjg.v21.i4.1081
10. Botto L.D., Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am. J. Epidemiol. 2000. Vol. 151(9). P. 862 - 877. DOI : https://doi.org/10.1093/oxfordjournals.aje.a010290
11. 1.Caldeira-Araъjo H., Ramos R., Florindo C., Rivera I., Castro R., Tavares de Almeida I. Homocysteine Metabolism in Children and Adolescents: Influence of Age on Plasma Biomarkers and Correspondent Genotype Interactions. Nutrients. 2019. Vol.11, # 646. DOI : https://doi.org/10.3390/nu11030646
12. Must A., Jacques P.F., Rogers G., Rosenberg IA., Selhub J. Serum Total Homocysteine Concentrations in Children and Adolescents: Results from the Third National Health and Nutrition Examination Survey (NHANES III). The Journal of Nutrition. 2003. Vol. 133, Issue 8. P. 2643-2649. DOI : https://doi.org/10.1093/jn/133.8.2643
13. Љkovierovб H., Vidomanovб E., Mahmood S. et al. The molecular and cellular effect of homocysteine metabolism imbalance on human health. Int J Mol Sci. 2016. Vol. 17(10). P. 1710 - 1733. DOI : https://doi.org/10.3390/ijms17101733
14. Gariglio L., Riviere S., Morales A., Rafael P. Comparison of homocysteinemia and MTHFR677CT polymorphism with Framingham Coronary Heart Risk Score. Archs Cardiol Mex. 2014. Vol. 84(2). P. 71 - 78. DOI : 10.1016/j.acmx.2013.12.006
15. Загальнодозиметрична паспортизація та результати ЛВЛ-моніторингу в населених пунктах України, які зазнали радіоактивного забруднення після Чорнобильської катастрофи. Дані за 2011 рік. Збірка 14. МОЗ України, НАМН України, МНС України, ДАЗВ, ДУ "ННЦРМ НАМН України", НД ІРЗ АТН України. K., 2012. 99 с.
16. Bazyka D.A., Fedirko P.A., Vasylenko V.V. et al. Results of WBC – monitoring of firefighters participating in response to Chornobyl forest fires in April-May 2020. Problems of Radiation Medicine and Radiobiology. 2020. Vol. 25. P. 177-187. DOI : https://doi.org/10.33145/23048336202025177187
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